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Vol. 16, Art. 111 (pp. 1282-1301)    |    2015       

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Modern methods of treatment of intestinal dysbiosis in patients with colon cancer.

A.A. Zakharenko,A.N. Suvorov, I.V. Shlyk, O.A. Ten, A.S. Natkha, A.A. Trushin, M.A. Belyaev, D.O. Akulichev, S.R. Dzhamilov, D.A. Zaycev, V.A. Rybalchenko.

I.P.Pavlov First Saint Petersburg State Medical University

Brief summary

In patients with colorectal cancer in the perioperative period, revealed pronounced changes microbiocenosis of colon, which is characterized by a change in the quantitative and qualitative composition of microflora. It showed a significant inhibition of anaerobic microbial component mainly bifidobacteria and lactobacilli. As a result, saprophytic microbes multiply with highly resistant to drugs, acquire pathogenic properties. The most prominent representative of such microorganisms is a pathogenic strain of Clostridium difficile, often provokes the development of pseudomembranous colitis. Depending on the degree of dysbiosis held various schemes of conservative therapy, and in severe dysbiotic changes, including pronounced diarrhea associated Clostridium dificile - fecal transplantation.


Key words

colorectal cancer, colon dysbiosis, antibiotic-associated diarrhea, fecal transplantation.

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