1. Scientific Research Institute of Oncology named after N.N. Petrov
2. North-Western State Medical University named after I.I. Mechnikov
3. Pavlov First Saint Petersburg State Medical University
Brief summary
The results of molecular-genetic study of the expression of genes BRCA1, c-kit mutation and EGFR gene and ALK translocation in 34 patients with neuroendocrine tumors (NETs) of the gastrointestinal tract. Based on the analysis results NET survival, depending on the level of expression of BRCA1, is allowed to assume the possibility of using this index as a prognostic criterion and the factor that determines the appropriateness of the appointment of platinum. The absence of the effect of the expression of c-kit in the survival rates of patients with NETs. EGFR gene mutations and ALK translocations have been identified in the material.
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