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Vol. 12, Art. 100 (pp. 1227-1234)    |    2011       

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New biomarkers in early diagnostics of cerebrovascular pathology: diffusive intima-medial thickness of the carotid arteries

V.A.Myasoedova, T.V.Kirichenko, D.M.Merkulova, I.A.Sobenin, Yu.A.Merkulov, N.M. Muhamedova, D.M. Martirosyan, V.P.Karagodin, А.N.Оrekhov

Institute for Atherosclerosis Research
Institute of General Pathology and Pathophysiology

Brief summary

A cross-sectional study of intima-medial thickness (IMT) of the carotid arteries in men and women in different age groups was performed as well as a prospective study of the dynamics of carotid IMT changes. The aim of the present study was the investigation of association between changes in neurological status and the presence of atherosclerotic lesions in carotid arteries. The diffuse thickening of intimа-medial layer of carotid arteries was been revealed to be an independent risk factor determining even minimally pronounced subclinical changes in the work of the central nervous system at the earliest stages of formation of the cerebrovascular pathology. It is established that the age is the key factor defining degree of development of an atherosclerosis in carotid arteries. It was shown that at the ages 40-70 years IMT is higher in men then in women, but at age after 70 such difference disappears due to acceleration of atherosclerosis progression in women, which starts after 58. Atherosclerosis progresses at uneven rate, both in men and women, and there are age periods characterized with different rate of IMT progression. In women, the most active progression of atherosclerosis starts 8 years later than in men, and is associated with the onset of late menopausal period.


Key words

carotid arteries, intima-medial thickness, ultrasonic scanning, atherosclerosis, gender differences.

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Журнал основан 16 ноября 2000г.
Выдано Министерством РФ по делам печати, телерадиовещания и средств массовых коммуникаций

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