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Клиническая медицина » Хирургия • Онкология, лучевая терапия
Том: 9 Статья: « 21 » Страницы:. 240-254 Опубликована в журнале: ноябрь 2008 г. English version Нестабильность митохондриальной и ядерной ДНК в клетках периферической крови онкологических больных при проведении радио-химиотерапииПатрушева В.Е.1, Патрушев М.В.1,2, Ушакова Т.Е.1, Газиев А.И.1
1Институт теоретической и экспериментальной биофизики РАН, Пущино, 2Российский Государственный университет им. И.Канта, Калининград
Резюме
Терапия онкологических заболеваний предполагает использование заведомо генотоксичеких факторов, направленных на подавление роста пролифирирующих клеток. Негативное влияние генотоксических агентов на нормальные ткани заставляет разрабатывать методы оценки генотоксического груза, с целью предотвращения летальных исходов, вызванных неспецифическим действием цитостатиков. В настоящей работе мы продемонстрировали один из вариантов оценки генотоксического действия радио-химиотерапии. Показано, что при использовании облучения и цитостатических антибиотиков, у некоторых пациентов, возрастает количество фрагментов мтДНК в крови. Повышенный уровень мтДНК соотносится с изменением генотипических комбинаций аллельных вариантов STR - локусов. Ключевые слова терапия, заболевания, онология, днк, радио-химиотерапия, кровь, неинвазивный метод (статья в формате PDF. Для просмотра необходим Adobe Acrobat Reader) открыть статью в новом окне Список литературы 1. Donnelly J.G. 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