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Федеральное государственное бюджетное учреждение науки
Институт теоретической и экспериментальной биофизики
Российской академии наук


ООО "ИЦ КОМКОН"


ФГБУН "Институт токсикологии" ФМБА России

Адрес редакции и реквизиты

192012, Санкт-Петербург, ул.Бабушкина, д.82 к.2, литера А, кв.378

Свидетельство о регистрации электронного периодического издания ЭЛ № ФС 77-37726 от 13.10.2009
Выдано - Роскомнадзор

ISSN 1999-6314


Фундаментальные исследования • Фармакология

Том: 25
Статья: « 38 »
Страницы:. 697-740
Опубликована в журнале: 10 декабря 2024 г.

English version

Применение циклодекстринов для оптимизации фармацевтических свойств препаратов при создании лекарственных форм (Обзор литературы)

Орлова А.Б., Иванов И.М., Свентицкая А.М., Никифоров А.С.

ФГБУ «Государственный научно-исследовательский испытательный институт военной медицины» Министерства обороны Российской Федерации


Резюме
Циклодекстрины (CD) нашли широкое применение в области создания лекарственных форм препаратов, не обладающих оптимальными физико-химическими и фармацевтическими свойствам (малая водная растворимость, низкая стабильность в растворах, выраженное местнораздражающее действие). Эффективность и целесообразность использования CD в лекарственных формах подтверждается немалым число разрешенных к клиническому применению лекарственных препаратов на их основе. В обзоре приведены общие сведения о CD и примеры разрешенных препаратов на их основе, охарактеризована их собственная токсичность при разных путях введения. Рассмотрены механизмы снижения местнораздражающего действия препаратов в комплексе с CD. Систематизированы примеры использования CD для создания парентеральных, пероральных, ингаляционных, офтальмологических и интраназальных форм лекарственных препаратов.


Ключевые слова
циклодекстрины, супрамолекулярная система, лекарственная форма, стабильность, местнораздражающее действие, биодоступность, назальная лекарственная форма



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