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Федеральное государственное бюджетное учреждение науки
Институт теоретической и экспериментальной биофизики
Российской академии наук


ООО "ИЦ КОМКОН"

ФГБУН "Институт токсикологии" ФМБА России

Адрес редакции и реквизиты

192012, Санкт-Петербург, ул.Бабушкина, д.82 к.2, литера А, кв.378

Свидетельство о регистрации электронного периодического издания ЭЛ № ФС 77-37726 от 13.10.2009
Выдано - Роскомнадзор

ISSN 1999-6314


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Том: 24
Статья: « 1 »
Страницы:. 1-16
Опубликована в журнале: 9 января 2023 г.
English version

Молекулярно-генетические особенности везикуло-мембранного snare-комплекса, ассоциированные с развитием нейродегенеративных заболеваний

Антонова Е.Н., Бабкин А.В., Кравцов И.С., Махлай А.А., Иванов И.М., Юдин М.А.

Государственный научно-исследовательский испытательный институт Министерства обороны Российской Федерации
ФГБОУ ВО СЗГМУ им. И. И. Мечникова Минздрава РФ


Резюме
В обзоре рассмотрены строение, функционирование и молекулярно-генетические особенности основных белков везикуло-мембранного SNARE-комплекса (синтаксина-1, SNAP-25, Munc13-1, Munc18-1, синаптобревина-2). Проанализированы структурные особенности (полиморфизм) и уровень экспрессии генов, кодирующих SNARE-белки на предмет наличия ассоциации с фенотипическими особенностями и риском развития заболеваний центральной и периферической нервной системы у человека и животных. Подчеркнута актуальность исследований по поиску связи отдельных молекулярно-генетических особенностей SNARE-комплекса с развитием нейродегенеративных заболеваний. Отмечена целесообразность учета вариантов и уровня экспрессии генов, кодирующих белки SNARE-комплекса, для прогнозирования развития и разработки персонализированного подхода к лечению нейродегенеративных заболеваний


Ключевые слова
SNARE белки, синтаксин-1, SNAP-25, Munc13-1, Munc18-1, синаптобревин-2, нейродегенеративные заболевания, ген, полиморфизм, персонализированный подход.


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