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Федеральное государственное бюджетное учреждение науки
Институт теоретической и экспериментальной биофизики
Российской академии наук


ООО "ИЦ КОМКОН"

ФГБУН "Институт токсикологии" ФМБА России

Адрес редакции и реквизиты

192012, Санкт-Петербург, ул.Бабушкина, д.82 к.2, литера А, кв.378

Свидетельство о регистрации электронного периодического издания ЭЛ № ФС 77-37726 от 13.10.2009
Выдано - Роскомнадзор

ISSN 1999-6314


Клиническая медицина » Хирургия • Травматология

Том: 23
Статья: « 27 »
Страницы:. 432-480
Опубликована в журнале: 10 июня 2022 г.
English version

Нарушения метаболизма селена при ортопедических заболеваниях (обзор литературы)

Хальчицкий С.Е.1, Буслов К.Г.1, Ли А.О.1, Комов Ю.В.2, Батоцыренова Е.Г.2, Кашуро В.А.2,3,4.

1 ФГБУ «Национальный медицинский исследовательский центр детской травматологии и ортопедии им. Г.И. Турнера» Минздрава России, г. Санкт-Петербург, РФ
2 ФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет» Минздрава России, г. Санкт-Петербург, РФ
3 ФГБОУ ВО «Российский государственный педагогический университет им. А.И.Герцена», г. Санкт-Петербург, РФ
4 ФГБГОУ ВО «Санкт-Петербургский государственный университет», г. Санкт-Петербург, РФ


Резюме
Селен (Se) считается важным микроэлементом, поскольку он является структурным компонентом антиоксидантных ферментов; однако на его концентрацию могут влиять диета, лекарства и генетические полиморфизмы. Роль селена в основном играют селенопротеины, синтезируемые системой метаболизма селена. Селенопротеины выполняют широкий спектр клеточных функций, включая регуляцию транспорта селена, гормонов щитовидной железы, иммунитета и окислительно-восстановительного гомеостаза. Дефицит селена способствует развитию ортопедических заболеваний, таких как остеоартрит (ОА) и ревматоидный артрит (РА) и др. В обзоре обсуждаются различные аспекты недостаточности селена, влияние на патологические процессы в организме, а также пищевые и фармакологические методы коррекции патологических состояний.


Ключевые слова
селен, селенопротеины, остеоартрит, ревматоидный артрит, пищевая и фармакологическая коррекция.


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