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Vol. 22, Art. 1 (pp. 1-20)    |    2021       

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Effect of long-term use of morphine hydrochloride and subsequent administration of neuropeptides to maternal individuals before pregnancy on the offspring development in the postnatal period

FSBUN IT FMBA Federal State Budgetary Institution of Science «Institute of toxicology of the Federal medical-biological agency»
FSBNU NII MT Federal State Budgetary Science Institution «Scentific institute of occupational medicine named after academician N.F. Izmerova»
FSBEI HE StPSCPU Federal State Budgetary Educational Institution of Hight Education «Sant-Petersburg State Chemical and Pharmaceutical University»

Brief summary

The study purpose was the assessment the of morphine hydrochloride (MHC) and the subsequent use of delta-sleep inducing peptide (DSIP) and an analog of fragment 4-10 of adrenocorticotropic hormone (4-10ACTH) effects in maternal individuals before pregnancy on the offspring development in the postnatal period. The study was realised in two stages. At the first stage, female rats from the age of one month were intragastrically inputed with morphine hydrochloride for 3 months, followed by peptide preparations for 2 weeks, after which they mated with intact males. At the second stage, the the born offspring parameters of physical and sensory-motor development were studied in according to standard methods, as well as behavioral reactions were studied in the "cross-shaped maze" test. For a comprehensive assessment of the offspring development in the postnatal period, the indices of physical and sensory-motor development were used, and the index of harmony of development was calculated. It was found that DSIP and 4-10ACTH are able to a large extent eliminate violations of physical and sensory-motor development in offspring whose maternal individuals received MHC for a long time before pregnancy. This indicates that the investigated peptide preparations can have a regulatory effect not only on the disorders of the hypothalamic-pituitary-gonadal axis of maternal individuals caused by prolonged use of MCH, but also on the hypothalamic-pituitary system of their offspring in the postnatal period of development. This fact allows us to attribute medicines containing DSIP and an analog of the fragment 4-10ACTH to the means of etiopathogenetic therapy of reproductive disorders caused by the use of narcotic analgesics.


Key words

morphine hydrochloride, neuropeptides, fragment 4-10 of adrenocorticotropic hormone, semax, delta sleep inducing peptide, deltaferox, offspring physical development, offspring sensory-motor development, postnatal development, reproductive function

Reference list

1. Zech, D.F. Validation of World Health Organization guidelines for cancer pain relief: A 10-year prospective study / D.F. Zech, S. Grond, J. Lynch [et al.] // Pain. - 1995. - Vol.63, 1. - P.65-76.


2. Mystakidou, K. Pain management of cancer patients with transdermal fentanyl: a study of 1828 step I, II, & III transfers / K. Mystakidou, E. Parpa, E. Tsilika [et al.] // J. Pain. - 2004. - Vol.5, 2. - P.119-132.


3. Abyzarova, G.R. Opiatnie analgetiki dlya terapii hronicheskoi boli y onkologicheskih bolnih v Rossii. Istoriya voprosa i perspektivi / G.R. Abyzarova, V.E. Horonenko, R.R. Sarmanaeva // Anasteziologiya i reanimatologiya 2015. - 1. - S.19-25.


4. Zvartay, M.V. Opioidnie analgetiki: pyti sovershenstvovaniya terapii bolevih sindromov / M.V. Zvartay, E.E. Pchelincev, A.N. Kybinin // Rysskii medicinskii jyrnal, «Chelovek i lekarstvo». Aktyalnie voprosi medicini». - 2007. - T.15, 5. - S.417


5. Ananeva, L.P. Primenenie narkoticheskih analgetikov pri lechenii hronicheskoi neonkologicheskoi boli / L.P. Ananeva // RMJ. - 2008. - S.21


6. Nicholson, B. Responsible prescribing of opioids for the management of chronic pain / B. Nicholson // Drugs. - 2003. - Vol.63, 1. - P.17-32.


7. Shtribel, H.V. Terapiya hronicheskoi boli. Prakticheskoe rykovodstvo / Per. s nem. red. N.A. Osipova, A.B. Danilova, V.M. Osipova. - M.: «GEOTAR-Media», 2005. - 303 s.


8. Savva, N.A. Neobhodimie shagi po ylychsheniu obezbolivaniya y detei v Rossii / N.A. Savva, E.V. Kymirova, A.A. Maschan // Palliativnaya medicina i reabilitaciya. - 2013. - 4. - S.10-13.


9. Shtribel, H.V. Terapiya hronicheskoi boli. Prakticheskoe rykovodstvo / H.V.. Shtribel / Per. s nem. red. N.A. Osipova [i dr.]. - M.: «GEOTAR-Media», 2005. - 303 s.


10. Richardson, E. Increased risk of reproductive dysfunction in women prescribed opioids for musculoskeletal pain: a matched cohort study in the Clinical Practice Research Datalink / E. Richardson, J. Bedson, Y. Chen [et al.] // Eur. J. Pain. - 2018. - Vol.22, 9. - P.1701-1708.


11. Vasechkin, V.B. Narkologicheskii dispanser ?12 g. Moskva Opiinaya narkomaniya i ee negativnie effekti v period beremennosti i na prenatalnom i neonatalnom etapah razvitiya rebenka // Voprosi narkologii. - 2000. - 5. - S.65-73.


12. Sivochalova, O.V. Deistvie ksenobiotikov na processi reprodykcii / O.V. Sivochalova, M.A. Fesenko / v kn.: Obshaya toksikologiya / pod red. B.A. Kyrlyandskogo, V.A. Filova. - M.: «Medicina», 2002. - S.445-468.


13. Arytunyan, A.V. Naryshenie neiromediatornogo zvena gipotalomicheskoi regylyacii reprodyktivnoi fynkcii pod vliyaniem neirotoksicheskih ksenobiotikov / A.V. Arytunyan, M.G. Stepanov, A.V. Korenevskii // Neirohimiya. - 1998.- T.15, ?4. - S.264-270.


14. Smith, C.G. Drug abuse and reproduction / C.G. Smith, R.H. Asch // Fertility and sterility. - 1987. - Vol.48, ?3. - P.355-373.


15. Hollister, L.E. Human pharmacology of drugs of abuse with emphasis on neuroendocrine effects / L.E. Hollister // Prog. Brain Res. - 1973. - Vol.39. - P.373


16. Smith, C.G. Drug abuse and reproduction / C.G. Smith, R.H. Asch // Fertility and sterility. - 1987. - Vol.48, ?3. - P.355-373.


17. Scolt, G. Danforths obstetrics and gynecology / G. Scolt, P. Saia, C. Hammond [et al.]. - Lippincott Willianis Wilkins, 1999. - 1155 r.


18. Arytunyan, A.V. Narysheniya gipotalomicheskoi regylyacii reprodyktivnoi fynkcii pri vozdeistvii neirotoksicheskih soedinenii i melatonina / A.V. Arytunyan, M.G. Stepanov, G.O. Kerkeshko E.K. Ailamazyan // Materiali mejdynarodnogo kongressa «Okryjaushaya sreda i perinatalnaya medicina» // Jyrnal Akysherstva i jenskih boleznei. - 2003. - T.LII, Vip 2, - S.77-85.


19. Korneeva, I.E. Sovremennaya koncepciya diagnostiki i lecheniya besplodiya v brake: avtoref. dis. dokt. med. nayk: 14.00.01. / Korneeva Irina Evgenevnv.- M., 2003. - 38 s.


20. Nazarenko, T.A. Jenskoe besplodie, obyslovlennoe narysheniyami processa ovylyacii (klinika, diagnostika, lechenie): avtoref. dis. dokt. med. nayk: 14.00.01 / Nazarenko Tatyana Alekseevna : - M., 1998. - 39 s.


21. Ovsyannikova, T.V. Endokrinnoe besplodie y jenshin pri giperprolaktinemii / T.V. Ovsyannikova // Ginekologiya. - 2004. - T.6, 3. - S.121-123.


22. Besplodnii brak /pod red. V.E. Radzinskogo - M.: GEOTAR-Media, 2019. - 401 s.


23. Ginekologiya. Nacionalnoe rykovodstvo / pod red. V.I. Kylakova - M.: GEOTAR-Media, 2011. - 1070 s.


24. Belyakova, N.A. Korrekciya peptidnimi preparatami naryshenii reprodyktivnoi fynkcii samok kris, vizvannih dlitelnim primeneniem morfina / N.A. Belyakova, E.U. Bonitenko, A.V. Nosov, K.E. Bonitenko // Rossiiskii biomedicinskii jyrnal Medline. ru.− 2019 .− T.20, St.9. − S.81-93.


25. Pravila laboratornoi praktiki. Prikaz Ministerstva zdravoohraneniya i socialnogo razvitiya Rossiiskoi Federacii ot 23 avgysta 2010 g. 708n g. Moskva. Zaregistrirovan v Minuste RF 13 oktyabrya 2010 g. Registracionnii 18713.


26. Belyakova, N.A. Razvitie potomstva, novie podhodi k ocenke v eksperimentalnoi biologii i medicine / N.A. Belyakova, E.U. Bonitenko, A.V. Nosov // Medline. - 2020. - T.21, St.87. - S.1115-1133.


27. Beili, N. Statisticheskie metodi v biologii / N. Beili - M.: «Mir», 1963. - 271 s.


28. Rebrova, O.U. Statisticheskii analiz medicinskih dannih. Primenenie paketa prikladnoi programmi STATISTICA / O.U. Rebrova. - M.: «Media Sfera», 2002 - 312 s.

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