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Vol. 15, Art. 17 (pp. 185-194)    |    2014       

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Nephroprotective properties of hydrochlorothiazide and the gravitational effects in experimental postischemic acute renal failure

Zaitсeva E.N., Frolova E.V., Chernova N.V.

State budgetary educational institution of higher professional education «Samara state medical University»

Brief summary

In experiments on white rats that hydrochlorothiazide (at a dose of 20 mg/kg, intragastric) on the background of gravitational effects (3g in the direction of the vector centrifugal acceleration to the kidneys animal) the daily exposure in the development of the postischemic acute renal failure increases speed glomerular filtration, reduces the level of creatinine in the blood, increases creatininuresis, reduces urinary excretion of protein, lactate dehydrogenase, γ- glutamyltransferase, and lowers the Doppler index resistance renal artery.


Key words

hydrochlorothiazide, the gravitational influence, diuretic activity, excretory function of the kidneys, acute renal failure, nephroprotective action, the Doppler index resistance renal artery.

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