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Клиническая медицина » Хирургия • Онкология, лучевая терапия
Том: 15 Статья: « 52 » Страницы:. 649-671 Опубликована в журнале: 30 сентября 2014 г. English version Рак эндометрия: гетерогенность и генетические маркеры.Чернобровкина А.Е., Свирин Н.А.
Государственное бюджетное учреждение здравоохранения «Санкт-Петербургский клинический научно-практический центр специализированных видов медицинской помощи (онкологический)».
Резюме
Проводится оценка молекулярно-генетического тестирования для определения прогностических и предиктивных характеристик различных генетических вариантов рака эндометрия. В последнее время решение этой проблемы во многом связывают с медико-генетическими исследованиями, направленными на изучение роли наследственной предрасположенности к развитию рака эндометрия и выявлению лиц с потенциально высоким риском заболевания. Все это подтверждает необходимость проведения дальнейшего изучения генетических основ рака эндометрия, которое позволит оптимизировать алгоритмы ранней диагностики, патогенетически обоснованной профилактики и лечебных мероприятий. Подводя итоги, следует признать, что мутационный фон рака эндометрия является комплексным, многофакторным и гетерогенным параметром не только между, но также и внутри каждого подтипа (I и II) РЭ. Необходимо подчеркнуть, что указанные в данном обзоре мутации в PIK3CA, PIK3R1, KRAS и PTEN не являются специфичными, и различные поломки и их взаимодействия с известными раковыми генами на пути разгадки. Более вдумчивое понимание, что первый и второй типы РЭ являются генетически отличительными друг от друга, будет шагом навстречу к совершенствованию будущих клинических испытаний. Ключевые слова рак эндометрия, PIK3CA, PIK3R1, KRAS, PTEN, MSI, EGFR (статья в формате PDF. Для просмотра необходим Adobe Acrobat Reader) открыть статью в новом окне Список литературы 1. Aarnio M, Sankila R, Pukkala E, Salovaara R, Aaltonen LA, de la Chapelle A, Peltomäki P, Mecklin JP, Järvinen HJ. Cancer risk in mutation carriers of DNA-mismatch-repair genes. // Int J Cancer. 1999; 81(2):214–218. 2. Akbay E, et al. Differential Roles of Telomere Attrition in Type I and II Endometrial Carcinogenesis. // American Journal of Pathology. –2008.–Vol. 173.–No. 2. –P. 536–544. 3. American Cancer Society. 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