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 УЧРЕДИТЕЛИ:
Институт теоретической и экспериментальной биофизики Российской академии наук.

ООО "ИЦ КОМКОН"

ФГБУН "Институт токсикологии" ФМБА России




Адрес редакции и реквизиты

192012, Санкт-Петербург, ул.Бабушкина, д.82 к.2, литера А, кв.378

Свидетельство о регистрации электронного периодического издания ЭЛ № ФС 77-37726 от 13.10.2009
Выдано - Роскомнадзор

ISSN 1999-6314

Российская поисковая система
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«
Vol. 12, Art. 93 (pp. 1147-1155)    |    2011       
»

Immune cholesterol level in blood - prognostic value for clinical implications
I.A. Sobenin*, V.P.Karagodin A.А. Melnichenko, А.N.Оrekhov*

Institute for Atherosclerosis Research: 4-1 I. Franko Str., 121355, Moscow, Russia.

*- Institute of General Pathology and Pathophysiology: 8 Baltiyskaya Str., 125315, Moscow, Russia.



Brief summary

It has been shown that the high level of LDL-containing circulating immune complexes (immune cholesterol) is characteristic for both coronary and extracoronary atherosclerosis. In the present 2-years prospective study, the diagnostic and prognostic significance of immune cholesterol was assessed in 98 asymptomatic men aged 40-74 with early atherosclerosis. The rate of carotid atherosclerosis progression was estimated by high-resolution B-mode ultrasonography as the increase in carotid intima-media thickness (IMT) of common carotid arteries. The patients with elevated baseline levels of immune cholesterol were characterized by significantly higher levels of total and LDL cholesterol as well as significantly increased mean IMT of common carotid arteries. Among all baseline lipid parameters, only immune cholesterol and LDL cholesterol were contingent with the extent of early carotid atherosclerosis (p=0.042 and p=0.049, respectively) and had the highest levels of relative risk and odds ratio. Carotid atherosclerosis progression was characterized by slow IMT increase at a rate of 0.029±0.011 mm per two years over the mean baseline IMT of 0.939±0.015 mm (p=0.028). A significant IMT increase was registered in 53.1% (n=52) patients, IMT significant reduction was observed in 21.4% (n=21) patients. The increased level of immune cholesterol along with total serum cholesterol and LDL cholesterol had rather high prognostic significance with the respect of atherosclerosis progression. The normal level of immune cholesterol (below than 16.0 μg/ml) was the only lipid parameter that predicted the absence of carotid atherosclerosis progression for two following years at prognostic value of 78.3%. The results of the study allow assuming that immune cholesterol level may be employed not only as a marker of early atherosclerosis, but also has a sufficient prognostic value for clinical implications.


Key words

atherosclerosis, low density lipoproteins, circulating immune complexes, ultrasonography, intima-media thickness.





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Reference list

1. Orekhov A.N., Tertov V.V., Novikov I.D. et al. 1985. Lipids in cells of atherosclerotic and uninvolved human aorta. I. Lipid composition of aortic tissue and enzyme-isolated and cultured cells. Exp. Mol. Pathol. 42: 117-137.


2. Orekhov A.N., Tertov V.V., Mukhin D.N., Mikhailenko I.A. 1989. Modification of low density lipoprotein by desialylation causes lipid accumulation in cultured cells: discovery of desialylated lipoprotein with altered cellular metabolism in the blood of atherosclerotic patients. Biochem. Biophys. Res. Commun. 162: 206-211.


3. Tertov V.V., Orekhov A.N., Sayadyan K.S. et al. 1990. Correlation between cholesterol content in circulating immune complexes and atherogenic properties of CHD patients' serum manifested in cell culture. Atherosclerosis. 81: 183-189.


4. Tertov V.V., Orekhov A.N., Kacharava A.G. et al. 1990. Low density lipoprotein-containing circulating immune complexes and coronary atherosclerosis. Exp. Mol. Pathol. 52: 300-308.


5. Orekhov A.N., Tertov V.V., Kudryashov S.A., Smirnov V.N. 1990. Triggerlike stimulation of cholesterol accumulation and DNA and extracellular matrix synthesis induced by atherogenic serum or low density lipoprotein in cultured cells. Circ. Res. 66: 311-320.


6. Orekhov A.N., Kalenich O.S., Tertov V.V. et al. 1995. Diagnostic value of immune cholesterol as a marker for atherosclerosis. J. Cardiovasc. Risk. 2: 459-466.


7. Salonen R., Nyyssonen K., Porkkala E. et al. 1995. Kuopio Atherosclerosis Prevention Study (KAPS). A population-based primary preventive trial of the effect of LDL lowering on atherosclerotic progression in carotid and femoral arteries. Circulation. 92: 1758-1764.


8. Yla-Herttuala S., Palinski W., Rosenfeld M.E. et al. 1989. Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man. J. Clin. Invest. 84: 1086-1095.


9. Szondy E., Horvath M., Mezey Z. et al. 1983. Free and complexed anti-lipoprotein antibodies in vascular diseases. Atherosclerosis. 49: 69-77.


10. Orekhov A.N., Kalenich O.S., Tertov V.V., Novikov I.D. 1991. Lipoprotein immune complexes as markers of atherosclerosis. Int. J. Tissue React. 13: 233-236.


11. Tertov V.V., Sobenin I.A., Orekhov A.N. et al. 1996. Characteristics of low density lipoprotein isolated from circulating immune complexes. Atherosclerosis. 122: 191-199.


12. Klimov A.N., Denisenko A.D., Vinogradov A.G. et al. 1988. Accumulation of cholesteryl esters in macrophages incubated with human lipoprotein-antibody autoimmune complex. Atherosclerosis. 74: 41-46.


13. Craven T.E., Ryu J.E., Espeland M.A. et al. 1990. Evaluation of the associations between carotid artery atherosclerosis and coronary artery stenosis. A case-control study. Circulation. 82: 1230-1242.


14. Puurunen M., Manttari M., Manninen V. et al. 1994. Antibody against oxidized low-density lipoprotein predicting myocardial infarction. Arch. Intern. Med. 154: 2605-2609.


15. Mustafa A., Nityanand S., Berglund L. et al. 2000. Circulating immune complexes in 50-yearold men as a strong and independent risk factor for myocardial infarction. Circulation. 102: 2576-2581.



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