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Vol. 12, Art. 54 (pp. 646-664)    |    2011       

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Management of patient with paralel current of multiple myeloma and primary myelofibrosis

S.S. Bessmeltsev, N.A. Romanenko, K.M. Abdulkadyrov, N.A. Potikhonova, M.N. Zenina, V.I. Rugal

Russian Research Institute of Hematology and Transfusiology, Russian Federal Medicobiological Agency, St.-Petersburg

Brief summary

In the article is presented the case report of a patient with simultaneously developed lymphoid and myeloid neoplasms. Diagnosis’s of multiple myeloma and primary myelofibrosis were confirmed by complete blood count, myelogramm, trephinebiopsy, immunohistochemical, cytogenetic, biochemical and x-ray’s examination. Complete remission of multiple myeloma was achieved after 7 cycles «VAD» and treatment with Recombinant Erythropoietin Beta during 11 weeks with subsequent maintenance therapy cycles of Bortezomib and Interferon Alpha. However, primary myelofibrosis was progressed to blastic crisis. Disease’s progression was delayed with 3 therapy cycles «5+2». But 3 months later hemorrhagic syndrome appeared and patient died.


Key words

multiple myeloma, primary myelofibrosis, erythropoietin, plasmatic cells, acute myeloid leukemia, anemia, bone destruction

Reference list

1. Andreeva N.E. Mielomnaya bolezn// Rykovodstvo po gematologii: v 2 t. T. 1/ Pod red. A.I. Vorobeva. 2-e izd. pererab. i dopol. M.: Medicina. - 1985. - S. 292-308.


2. Sozin S.E., Salogyb G.N. Slychai razvitiya ostrogo megakarioblastnogo leikoza (M7) y bolnoi s klinicheskoi remissiei mnojestvennoi mielomi// Klinicheskaya onkogematologiya. - 2008, №2. - S.141-144.


3. Vardiman J.M., Thiele Juergen, Arber D.A. et al. The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes// Blood. - 2009. Vol. 114, №5. - P. 937-951.


4. Palumbo A., Dringhen S., Zweegman S. et al. Secondary malignancies in elderly myeloma//Hematologica. - 2011 (13th International Myeloma Workshop). - Vol. 96. - S24 (Abstract).


5. Bessmelcev S.S., Abdylkadirov K.M. Mnojestvennaya mieloma. Sovremennii vzglyad na problemy// g. Almati. - 2007. - 480 s.


6. Takada M ., Umeda M ., Shikoshi K ., Shirai T . IgG lambda-type multiple myeloma associated with myelofibrosis accompanied by thrombocytosis// Rinsho Ketsueki. - 1991. - Vol. 32, №9. - P. 1001-1005.


7. Morgan G., Durie B., San Miguel J. et al. Retrospective analysis of the long term safety of lenalidomode ± dexamethasone in relapsed/refractory multiple myeloma patients: analysis of pooled date and incidence rates of second primary malignancy// Hematologica. - 2011 (13th International Myeloma Workshop). - Vol. 96. - S24 (Abstract).


8. Attal M., Olivier P., Cances Lauwers V. et al. Maintenance treatment with lenalidomide after transplantation for myeloma: analysis of secondary malignancies within the IFM 2005-02 trial// Hematologica. - 2011 (13th International Myeloma Workshop). - Vol. 96. - S23 (Abstract)].


9. Massa F.S., Rolón J.M., Pavlovsky S. Myelofibrosis with myeloid metaplasia in a patient with relapsed Hodgkin's lymphoma who underwent autologous hematopoietic stem cell transplantation// Hematology. - 2007. - Vol.12, №6. - P.487-488.


10. Jimenez-Zepeda V.H ., Dominguez-Martinez V.J. Plasma cell leukemia: a highly aggressive monoclonal gammopathy with a very poor prognosis// Int J Hematol. - 2009. - Vol. 89, №3. - P.259- 268.


11. Jimenez - Zepeda V . H ., Dominguez - Martinez V . J . Plasma cell leukemia: a rare condition// Ann Hematol. - 2006. - Vol. 85, №4. - P.263-267.


12. Kato M ., Umeda M., Kosuge T. et al. Idiopathic myelofibrosis transformed to acute myelomonocytic leukemia associated with non-Hodgkin's lymphoma// Rinsho Ketsueki. - 1994. - Vol. 35, №6. - P.581-587.


13. Nakase K., Hasegawa M., Susuki Y. et al. Myelofibrosis complicated by T-cell lymphoma followed by leukemic transformat// Rinsho Ketsueki. - 1995. - Vol. 36, №11. - P.1284-1288.


14. Dührsen U ., Uppenkamp M., Meusers P. et al. Frequent association of idiopathic myelofibrosis with plasma cell dyscrasias// Blut. - 1988. - Vol.56, №3. - P.97-102.


15. Kawauchi K., Mori H., Sugiyama H. et al. Multiple myeloma with coexistent myelofibrosis: Improvement of myelofibrosis following recovery from multiple myeloma after treatment with melphalan and prednisolon// Jpn. J. Med. - 1991. - Vol. 30, №5. - P. 483-486.


16. Kikukawa M., Umahara T., Kikawada M. et al. Peripheral T-cell lymphoma presenting as myelofibrosis with the expression of basic fibroblast growth factor//Geriatr Gerontol Int. - 2009. - Vol. 9, №4. - P.395-398.


17. Vandermolen L ., Rice L., Lynch E.C. Plasma cell dyscrasia with marrow fibrosis. Clinicopathologic syndrome// Am. J. Med. - 1985. - Vol.79, №3. - P.297-302.


18. Itoh K., Kashimura T., Kobayashi Y. et al. Atypical chronic myeloid leukemia presenting with trilineage dysplasia and IgG (lambda) type monoclonal gammopathy// Rinsho Ketsueki. - 1999. - Vol. 40. - P. 129-134.


19. Bessmelcev S.S., Abdylkadirov K.M. Mnojestvennaya mieloma// Gematologiya: Noveishii spravochnik/ pod obsh. red. K.M. Abdylkadirova. M.: Izd-vo Eksmo; SPb.: Izd-vo Sova, - 2004. - S.593-665.


20. Kubota Y., Waki M. Long-term remission of non-Hodgkin lymphoma secondary to the treatment for essential thrombocythemia// Rinsho Ketsueki. - 2009. - Vol. 50, №3. - P. 197-202.


21. Dimopoulos M., Kyle R., Fermand J. et al. Guidelines for standard investigative workup: report of the International Myeloma Workshop Consensus Panel 3// Blood. - 2011. - www.bloodjournal.org [at HOUSTON ACADEMY OF MEDICINE on February 3, 2011].


22. Votyakova O.M., Demina E.A. Mnojestvennaya mieloma// Klinicheskaya onkogematologiya: Rykovodstvo dlya vrachei/ pod red. M.A. Volkovoi. - M.: «Medicina», - 2007. - S. 847-873.


23. Bessmelcev S.S. Hronicheskii idiopaticheskii mielofibroz// Gematologiya: Noveishii spravochnik/ pod obsh. red. K.M. Abdylkadirova. M.: Izd-vo Eksmo; SPb.: Izd-vo Sova, - 2004. - S.556-571.


24. Demidova A.V. Hronicheskii idiopaticheskii mielofibroz// Klinicheskaya onkogematologiya: Rykovodstvo dlya vrachei/ pod red. M.A. Volkovoi. – M.: «Medicina», -2007. - S. 616-630.


25. Colagrande M ., Di Ianni M., Coletti G. et al. Toxic epidermal necrolysis in a patient with primary myelofibrosis receiving. thalidomide therapy// Int. J. Hematol. - 2009. - Vol.89, №1. - P.76- 79.


26. Zhang Y ., Li L., Nie L. et al. Clinical study on relationship between JAK2 V617F mutation and chronic myeloproliferative disorders// Zhonghua Xue Ye Xue Za Zhi. - 2008. - Vol.29, №2. - P.105- 109.


27. Mesa R. A., Verstovsek S., Cervantes F.. et al. Primary myelofibrosis (PMF), post polycythemia vera myelofibrosis (post-PV MF), post essential thrombocythemia myelofibrosis (post- ET MF), blast phase PMF (PMF-BP): Consensus on terminology by the international working group for myelofibrosis research and treatment (IWG-MRT)// Leuk Res. - 2007. - Vol.31, №6. - P.737-740.


28. Abildgaard N., Bendix-Hansen K., Kristensen J.E. et al. Bone marrow fibrosis and disease activity in multiple myeloma monitored by the aminoterminal propeptide of procollagen III in serum// Br J Haematol. - 1997. - Vol. 99, №3. - P.641-648.


29. Subramanian R., Basu D., Dutta T.K. Significance of bone marrow fibrosis in multiple myeloma// Pathology.- 2007. - Vol.39, №5. - P.512-515.


30. Vedrine L., Boucher E., Samson T. et al. Mieloid pseudo-splenomegaly in patient with a myeloma// Press Med. - 2002. - Vol. 31. - P. 1846-1848.


31. Stevenson J.P., Schwarting R., Schuster S.J. Analysis of clonality using X-linked polymorphisms in a patient with multiple myeloma and myelofibrosis// Am. J. Hematol. – 1998. - Vol.59, №1. - P.79-82.


32. de la Serna J ., Bornstein R., Lahuerta-Palacios J.J. The use of an expanded circulating hematopoietic progenitor cell pool associated with bone marrow fibrosis for the support of autologous transplantation in IgD multiple myeloma// Bone Marrow Transplant. - 1997. - Vol.19, №10. - P.1033- 1036.


33. Kanoh T ., Okuma M. IgD (lambda) multiple myeloma associated with myelofibrosis: an isolated case of nuclear physicist// Rinsho Ketsueki. - 1996. - Vol.37, №3. - P.244-248.


34. Mc Cluggage W.G ., Jones F.G, Hull D. et al. Sclerosing IgA multiple myeloma// Acta Haematol. - 1995. - Vol.94, №2. - P.98-101.


35. Murayama T ., Matsui T., Hayashi Y., et al. Plasma cell leukemia with myelofibrosis// Ann Hematol. - 1994. - Vol. 69, №3. - P. 151-152.


36. Abdylkadirov K.M. Hronicheskii idiopaticheskii mielofibroz// Klinicheskaya gematologiya: Spravochnik/ Pod red. K.M. Abdylkadirova. SPb: Piter, - 2006. - S.181-186.

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