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Vol. 12, Art. 5 (pp. 41-49) | jan 2011
№ гос. регистрации: 0421100002\0005
Changes of hormonal status in patients with disseminated prostate cancer after proton "hyporhysectomy"
Kondratiev B.V., Vinogradov V.M., Shalek R.A., Yalynych N.N., Pushkariova T.V., Kopaneva M.V.
Russian Research Center for Radiology and Surgical Technologies Federal Agency of High Medical Care Technology, Saint-Petersburg, 197758, Pesochny, Leningradskaya st., 70/4
Brief summary
Purpose: The evaluation of the hormonal changes in patients with metastatic prostate cancer after «hypophysectomy» by narrow proton beam as a stage of hormonal therapy. Material and Methods: 98 patients with disseminated prostate cancer had been irradiating on the synchrocyclotron PNPI (1000 MeV, Gatchina). Because of the high energy of the proton beam the rotating-convergent shoot-through technique had been using. The single dose of 80-100 Gy had been giving. The levels of prolactin, testosterone, cortisol and PSA had been evaluated before and annually after proton therapy in two groups of the patients: with the stabilization (n=46) and the progression (n=25) of the disease. Results: In the patients with the progression of the disease during the first year of study the level of prolactin was significantly higher (374,7±13,8 mME/l) than in the patients with the stabilization (203,9±8,0 mME/l, <0,05). A direct correlation between the levels of prolactin and PSA was detected (r=0,937 p<0,0001). The changes of testosterone level were not significant. The level of cortisol in the patients with the stabilization was significantly higher (566,4±18 nmol/l, p<0,05), than in the patients with the progression of the disease (352,5±14,94 nmol/l). An inverse correlation between the levels of cortisol and PSA was detected (r=-0,975 p<0,0001). Conclusion: Proton «hypophysectomy» is the stage of systemic therapy of patients with metastatic prostate cancer. Monitoring of hormonal changes is of great importance for palliative care of such patients. Key words proton irradiation, narrow beams, hypophysectomy, disseminated prostate cancer, hormones (The article in PDF format. For preview need Adobe Acrobat Reader)  Open article in new window
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