Опубликовать статью

Информационное партнерство

Инфоресурсы

Контакты

«

Vol. 10, Art. 23 (pp. 508-523)    |    2009       

»

Pathological changes of respiratory compartment of lung of mice by experimental avian influenza a/h5n1

Malkova E.M., Taranov O.S., Agafonov A.P., Demina O.K., Gricyk O.B., Sergeev A.A., Drozdov I.G.

Brief summary

Pathological changes of respiratory compartment of lung have been examined in three groups of outbread mice weithing 12-15 g which were intranasally infected with identical dose 10 LD50 of strains A/Chicken/Kurgan /05/2005, A/Duck/Kurgan /08/2005, A/Chicken/Suzdalka/Nov-11/2005. Six mice were used for each time point and each viruse. We revealed early development of the quickly progressing primary virus pneumonia, respiratory distress syndrome and the disseminated intravascular coagulation (DIC). All the strains caused expressed failure of haemodynamic and interstitial fibrosis of the lung tissue were detected.


Key words

influenza virus A/H5N1, mouse model, lung, acute respiratory syndrome, viral pneumonia

Reference list

1. Cinzerling A.V., Cinzerling V.A. Sovremennie infekcii. Patologicheskaya anatomiya i voprosi patogeneza.S-Peterbyrg, 2002.


2. Chan P. Outbreak of avian influenza A (H5N1) virus infection in Hong Kong in 1997. Clin. Infect. Dis. 2002, 1: 58-64.


3. Roberts H., Lim W.S. Viral lung infections and the potential for a human pandemic. Medicine. 2008, 36: 291-294.


4. Horimoto T., Kawaoka Y. Influenza: lessons from past pandemics, warnings from current incidents. Nat. Rev. Microbiol. 2005, 3: 591-600.


5. Sominina A.A., Sorokin E.V., Careva T.R., Korenyako I.E. Virys grippa A (H5N1) kak odin iz veroyatnih vozbyditelei predstoyashei pandemii. Citokini i vospalenie. 2006, 1: 3-9.


6. Claas E.C., Osterhaus A.D., van Beek J.C. et al. Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus. Lancet. 1998, 351: 472-477.


7. Subbarao A., Klimov A., Katz J. et al. Characterization of an avian influenza A (H5N1) virus isolated from a child with fatal respiratory illness. Science. 1998, 279: 393- 396.


8. Agafonov A.P., Demina O.K., Shikov A.N. i dr. Virys grippa ptic (H5N1) // Vakcinoypravlyaemie respiratornie virysnie infekcii. Gripp, kor, krasnyha, epidemicheskii parotit / Pod red. I.G.Drozdova. – Novosibirsk, 2008.


9. Rimmelzwaan G.F., Kuiken T., van Amerongen G. et al. Pathogenesis of influenza A (H5N1) virus infection in primate model. J. Virol. 2001, 75: 6687-6691.


10. Gao P., Watanabe S., Ito T. et al. Biological heterogeneity, including systemic replication in mice, of H5N1 influenza A virus isolated from humans in Hong Kong. J. Virol. 1999, 73: 3184-3189.


11. Lu X., Tumpey T.M., Morken T. et al. A mouse model for the evaluation of pathogenesis and immunity to influenza A (H5N1) viruses isolated from humans. J. Virol. 1999, 73: 5903-5911.


12. Dybing J.K., Schultz-Cherry K.S., Swayne D.E. et al. Distinct pathogenesis of Hong Kong H5N1 viruses in mice compared to that of other highly pathogenesis H5 avian influenza viruses. J. Virol. 2000, 74: 1443-1450.


13. Lipatov A.S., Evseenko V.A., Yen H.-L. et al. Influenza (H5N1) viruses in poultry, Russian Federation, 2005-2006. Emerging Infect. Dis. 2007. V.13, N 4. P.539-546.


14. Tanaka H., Park C., Ninomiya A. et al. Neurotripism of the 1997 Hong Kong H5N1 influenza virus in mice. Vet. Microbiology. 2003, 95: 1-13.


15. Cinzerling A.V. Etiologiya i patologicheskaya anatomiya ostrih respiratornih infekcii. L.: Medicina, 1977.


16. Bay A., Etlik O., Oner A.F. et al. Radiological and clinical course of pneumonia in patients with avian influenza H5N1. Eur. J. Radiol. 2007, 61: 245-250.


17. van Riel D., Munster V.J., de Wit E. et al. Human and avian influenza viruses target different cells in the lower respiratory tract of humans and other mammals. Am. J. Pathol. 2007, 171: 1215-1223.


18. Lowen A.C., Palese P. Influenza virus transmission: basic science and implications for the use of antiviral drugs during a pandemic. Infect. Disord. Drug Targets. 2007, 7: 318-328.


19. Bruder D., Srikiatkhachorn A., Enelow R.I. Cellular immunity and lung injury in respiratory virus infection. Viral. Immunol. 2006, 19: 147-155.


20. Ware L.B., Matthay M.A. The acute respiratory distress syndrome. N. Engl. J. Med. 2000, 342: 1334-1349.


21. Taubenberger J.K., Reid A.H., Lourens R.M. et al. Characterization of the 1918 influenza virus polymerase genes. Nature. 2005, 437: 889-893.


22. Cinzerling A.V., Anisimova U.N., Ioakimova N.V. Ostrie respiratornie infekcii y ymershih detei i rol DVS-sindroma pri etih zabolevaniyah. Arh. patol. 1990, 6: 7-12.


23. Osidak L.V., Jilinskaya I.N., Drinevskii V.P. i dr. Novii etiotropnii kompleks dlya lecheniya grippa. Detskie infekcii. 2004, 4: 54-57.

Журнал основан 16 ноября 2000г.
Выдано Министерством РФ по делам печати, телерадиовещания и средств массовых коммуникаций

(c) Перепечатка материалов сайта Medline.Ru возможна только с письменного разрешения редакции