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Vol. 10, Art. 22 (pp. 492-507)    |    2009       

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Pathological changes of conducting compartment of lung by experimental avian influenza a/h5n1

Malkova E.M., Taranov O.S., Agafonov A.P., Demina O.K., Gricyk O.B., Sergeev A.A., Drozdov I.G.

Brief summary

Pathological changes of conducting compartment of lung have been examined in three groups of outbread mice weithing 12-15 g which were intranasally infected with identical dose 10 LD50 of strains A/Chicken/Kurgan/05/2005, A/Duck/Kurgan/08/2005, A/Chicken/Suzdalka/Nov-11/2005. We revealed early development of the quickly alteration of bronchial epithelium, and suppurative inflammation, necrosis, ciliary dysfunction. Pathological changes were diffuse and included all layers of bronhi subdivisions.


Key words

influenza virus A/H5N1, mouse model, lung, bronchitis

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