The experience of the state scientific center of the Russian Federation - the federal medical and biophysical center named after A. I. Burnasyan of the federal medical and biological agency of russia in the treatment of acute radiation injuries cause
1 Federal State Budgetary Institution "State Scientific Center of the Russian Federation - Federal Medical Biophysical Center named after A.I. Burnazyan" of the Federal Medical and Biological Agency
123098, Russia, Moscow, st. Marshala Novikova, 23
2 Federal State Budgetary Educational Institution of Higher Education "Military Medical Academy named after S.M. Kirov" Ministry of Defense of the Russian Federation
Brief summary
The article presents the experience of the Federal State Budgetary Institution, the State Scientific Center of the Russian Federation - the A.I. Burnazyan Federal Medical Biophysical Center of the Federal Medical and Biological Agency - as a leading domestic specialized radiological medical center for the diagnosis and treatment of acute radiation injuries. As the successor to the Institute of Biophysics of the USSR Ministry of Health and Clinical Hospital No. 6 of the Moscow City Health Department, established in 1948, the State Research Center of the Russian Federation - the A.I. Burnazyan Federal Medical Biophysical Center of the Federal Medical and Biological Agency has significant experience, accounting for approximately two-thirds of the world's total, in treating patients with acute radiation sickness (acute radiation syndrome) and local radiation injuries (primarily to the skin and body segments) resulting from radiation accidents and incidents in the Soviet Union and the Russian Federation since 1949. This experience has been accumulated in the Case History Database, which contains information on 230 victims of acute radiation sickness (syndrome) in 38 radiation incidents. This article presents the structure of the Case History Database for individual types of acute radiation injuries resulting from radiation accidents and incidents from 1949 to 2024. Modern methods for the specific diagnosis and treatment of acute radiation injuries are discussed. The article concludes by describing the role of the Russian Federation State Research Center - the A.I. Burnazyan Federal Medical and Biophysical Center of the Federal Medical and Biological Agency - as a platform for intersectoral and international cooperation on the elimination of the medical consequences of radiation accidents and incidents in Russia and abroad.
Key words
Ionizing radiation; radiation accidents and incidents; acute radiation injuries; diagnostics; treatment; emergency response; international cooperation; interdepartmental cooperation
1. Postanovlenie Pravitelstva RF ot 25.04.2012 № 392 «O prisvoenii statysa Gosydarstvennogo naychnogo centra Rossiiskoi Federacii Federalnomy gosydarstvennomy budjetnomy ychrejdeniu "Federalnii medicinskii biofizicheskii centr im. A.I. Byrnazyana"». Available at: http://archive.government.ru/gov/results/18838 (data obrasheniya 24.12.2025).
2. Solovev V.U., Yiba V.V., Samoilov A.S. i dr. Radiacionnie incidenti na territorii bivshego SSSR v 1950-1991 gg. i v Rossiiskoi Federacii v 1992-2016 gg. s postradavshimi s diagnozom «ostraya lychevaya bolezn»: obzor. Medicina ekstremalnih sityacii. 2017; 60 (2): 119-127.
3. Karamyllin M.A., Chepyr S.V., Samohvalov I.M. i dr. Klinicheskie rekomendacii po profilaktike, diagnostike, lecheniu i reabilitacii pri ostrih radiacionnih porajeniyah: aktyalnost razrabotki i bazovaya klassifikaciya patologii. Vestnik Rossiiskoi voenno-medicinskoi akademii. 2024; 26(1): 87-100. https://doi.org/10.17816/brmma595865.
4. Samoylov A.S., Bushmanov A.Yu., Galstyan I.A. Medical Management: Major Lessons Learned from the Chernobyl Accident (the review). Journal of Radiological Protection. 2021; 41(3). https://doi.org/10.1088/1361-6498/ac14d4.
5. Gyskova A. K. Atomnaya otrasl strani glazami vracha. M.: Realnoe Vremya, 2004.
8. International Atomic Energy Agency. Medical management of radiation injuries, Safety Reports Series No. 101. Vienna: IAEA; 2020.
9. Fliedner T.M., Friesecke I., Beyrer K. (eds). Medical management of radiation accidents: Management of the acute radiation syndrome. London: The British Institute of Radiology; 2001.
10. Fliedner T.M. Radiologic and nuclear events: the METREPOL severity of effect grading system. Blood. 2008; 111(4): 5757-5758.
11. Gyskova A.K., Baranov A.E., Barabanova A.V. i dr. Diagnostika, klinicheskaya kartina i lechenie ostroi lychevoi bolezni y postradavshih na Chernobilskoi AES. Soobshenie 2. Nekostnomozgovie sindromi lychevih porajenii. Terapevticheskii arhiv. 1989; 8: 99-103.
12. Radiacionnaya medicina: rykovodstvo dlya vrachei-issledovatelei i organizatorov zdravoohraneniya. T. 2: Radiacionnie porajeniya cheloveka. Pod red. L.A. Ilina. M.: IzdAT, 2001.
13. Samoilov A.S., Konchalovskii M.V., Byshmanov A.U. i dr. Rekomendacii po diagnostike i lecheniu kostnomozgovoi formi ostroi lychevoi bolezni. Gematologiya i transfyziologiya. 2023; 68(1): 98-128. https://doi.org/10.35754/0234-5730-2023-68-1-98-128.
14. Pervaya vrachebnaya i kvalificirovannaya medicinskaya pomosh pri ostrih radiacionnih porajeniyah: prakticheskoe rykovodstvo / pod obshei red. prof. M.A. Karamyllina i prof. S. V. Chepyra. (Seriya «Okazanie medicinskoi pomoshi pri radiacionnih porajeniyah». Vip. 3). SPb: SpecLit, 2025.
15. Jaworska A., Ainsbury E.A., Fattibene A., et al. Operational guidance for radiation emergency response organisations in Europe for using biodosimetric tools developed in EU MULTIBIODOSE project. Radiat Prot Dosim. 2015; 164(1-2): 165-169. https://doi.org/10.1093/rpd/ncu294.
17. Swartz H.M ., Flood A.B., Gougelet R.M., et al. A critical assessment of biodosimetry methods for large-scale incidents. Helth Phys. 2010; 98(2): 95-107. https://doi.org/10.1097/HP.0b013e3181b8cffd.
18. Nygis V.U., Kozlova M.G, Nikitina V.A. Sovremennoe sostoyanie problemi citogeneticheskoi indikacii dozi. V sbornike statei, posvyashennih 70-letiu FGBY «GNC RF — FMBC imeni A.I. Byrnazyana» (1946-2016 gg.). Pod obsh. red. L.A. Ilina, V.V. Yiba, A.S. Samoilova. M.: FGBY GNC FMBC im. A.I. Byrnazyana FMBA Rossii; 2016: 222-237.
19. Olesova V.N., Smelcov A.V., Ilevich U.R i dr. Primenenie EPR-dozimetrii na mini-probah emali zyba. Rossiiskii stomatologicheskii jyrnal. 2010; 4: 15-17.
20. Romanyukha A., Trompier F., Reyes R.A. Q-band electron paramagnetic resonance dosimetry in tooth enamel: Biopsy procedure and determination of dose detection limit. Rad Environ Biophys. 2014; 53(2): 305-310. https://doi.org/10.1007/s00411-013-0511-8.
21. Gyskova A.K., Nadejina N.M., Metlyaeva N.A. i dr. Ostraya lychevaya bolezn. V knige: Reakcii organizma cheloveka na vozdeistvie opasnih i vrednih proizvodstvennih faktorov. T. 2. M.; 1991.
22. Barabanova A.V., Baranov A.E., Byshmanov A.U. i dr. Ostraya lychevaya bolezn cheloveka: atlas. M.: FMBC imeni A.I. Byrnazyana, 2017.
23. Samoilov A.S., Byshmanov A.U., Galstyan I.A., i dr. Opit lecheniya porajennih pri avarii na Chernobilskoi AES v ysloviyah specializirovannogo stacionara. Medicina katastrof. 2024. 3: 22-26. https://doi.org/10.33266/2070-1004-2024-3-22-26.
24. Baranov A.E., Geil R.P., Gyskova A.K. Transplantaciya kostnogo mozga posle obshego oblycheniya y postradavshih pri avarii na Chernobilskoi AES. Gematologiya i transfyziologiya. 1989; 34(3): 3-16.
25. Kotenko K.V., Eremin I.I., Moroz B.B., et al.. Cell technologies in the treatment of radiation burns: experience Burnasyan Federal Medical Biophysical Centre. Genes & Cells, 2012, 7(2): 97-102. https://doi.org/10.23868/gc121646.
26. Postanovlenie Pravitelstva RF ot 08.11.2013 N 1007 (red. ot 27.06.2025) "O silah i sredstvah edinoi gosydarstvennoi sistemi predyprejdeniya i likvidacii chrezvichainih sityacii". Available at: http://government.ru/docs/all/89251/ (data obrasheniya 24.12.2025).