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Vol. 26, Art. 6 (pp. 123-141)    |    2025       

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Markers of hereditary thrombophilia and the risk of deep vein thrombosis in older patients

Kapustin S.I.2, Svitina S.P.2, Soldatenkov V.Е.2, Burakov V.V.2, Nochrin S.P.1, Tomchenko A.I.1, Fomin К.N.1, Papayan L.P 2, Chechulova А.V.1, Homchuk I.А.1

1 St. Petersburg I. I. Dzhanelidze Research Institute of Emergency Medicine, Saint Petersburg, Russia
2 Russian Research Institute of Hematology and Transfusiology, FMBA of Russia, Saint Petersburg, Russia

Brief summary

Introduction: It is believed that hereditary VTE risk factors are more common in young patients. However, the role of hereditary VTE risk factors in older patients has not been fully determined. Materials and methods: 174 patients over 45 years of age with a newly diagnosed episode of VTЕ (venous thromboembolism). Molecular genetic typing of the polymorphism of 9 genes involved in the regulation of the plasma link of hemostasis from genomic DNA samples obtained from peripheral blood leukocytes was performed. Results: an increase in the proportion of carriers of mutations FII G20210A and FV G1691A was revealed among people with VTЕ, compared with the healthy population. Heterozygous carriage of mutations FII G20210A and FV G1691A was more common in men. Homozygous genotypes FXIII 34 Leu/Leu significantly prevailed in the group of women. Conclusions: Heterozygous variants FII 20210 G/A and FV 1691 G/A are risk factors for VTЕ in patients of all age groups, especially in men. Homozygous variant FXIII 34 Leu/Leu may be an independent risk factor for VTЕ in women, regardless of age.


Key words

congenital scoliosis, idiopathic scoliosis, genetics, GWAS, DISCO, progression, secondary curves

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