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Vol. 26, Art. 29 (pp. 715-728) | 2025
The initial generalizing hypothesis of the pathogenesis of open-angle glaucoma
Pankratov R.M.1, Svetlova O.V.2,3, Granadchikov V.A.4, Makarovskaya O.V.1,
Kantyukova G.A.5, Koshits I.N.6 1Ophthalmological Laser Clinic. Russia, 163002, Arkhangelsk, Obvodny Kanal Ave.,9 Building 2 2Federal State Budgetary Educational Institution of Higher Education “Academician I.P. Pavlov First St. Petersburg State Medical University” of the Ministry of Healthcare of Russian Federation. Russia, 197022, Saint-Petersburg, Lva Tolstogo street, 6-8; 3Federal State Budgetary Educational Institution of Higher Education “Mechnikov North-West State Medical University” of the Ministry of Healthcare of Russian Federation. Russia, St. Petersburg, 191015, Kirochnaya St., 41. 4Kislovodsk City Hospital. Russia, 357700, Kislovodsk, Kutuzova Str. 127 5Scientific and Clinical Center "Vision". Russia, 357700, Kislovodsk, Tsander Str. 2 6Petercom-Network / MS Consulting Group Cl. Corp. Russia, 194223, Saint-Petersburg, Kurchatov St.1
Brief summary
Despite the existence of many traditional and new proposed theories of the pathogenesis of open-angle glaucoma (OAG), there is still no generalizing hypothesis that allows reflecting the initial degree of influence of heredity in its occurrence and pathogenesis by determining the functional characteristics of the eye. In 2008, simple and reliable technologies for in vivo determination of the fundamental characteristics of the eye, such as fibrous membrane rigidity (FME) and sclera fluctuations, as important initial parameters in the diagnosis and treatment of OAG, were created and introduced into clinical practice in the Russian Federation. An analysis of the accumulated data set of several thousand patients over 15 years on the levels of FOG rigidity and scleral fluctuations in healthy and glaucoma-affected eyes showed that all eyes initially belong to three zones of rigidity - low, medium and high. These three zones of scleral rigidity are determined by heredity at the genetic level and, apparently, directly affect the development of normotensive and hypertensive forms of OAG Key words Ranges of eye rigidity, scleral fluctuation, pathogenesis of open-angle glaucoma (The article in PDF format. For preview need Adobe Acrobat Reader)  Open article in new window
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