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Vol. 25, Art. 33 (pp. 597-609)    |    2024       

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Development of a dosage form of opioid receptor antagonists for inhalation administration using a metered-dose powder inhaler

Pechurina T.B., Sventitskaya A.M., Ivanov I.M., Raguzin E.V., Nikiforov A.S.

Feredal State Budgetary Establishment «State Scientific Research Test Institute of the military medicine» Defense Ministry of the Russian Federation

Brief summary

Prevention of relapses of opioid addiction is considered one of the important medical and social problems. Opioid antagonists (naloxone, naltrexone, nalmefene) play a major role in specific pharmacological support. Existing dosage forms (oral and parenteral) do not fully contribute to treatment adherence. Intranasal and inhaled forms of opioid antagonists are considered promising. The paper investigates an approach to the production of micronized naloxone and naltrexone powder by spray drying, using a pharmaceutical impactor, the granulometric composition of the obtained powders and the quality indicators of the dosage form in the composition of the Aerolizer metered powder inhaler, as well as the stability of the samples during storage, are characterized. It was shown that the naltrexone sample with an active principle content of 25 mg in a capsule was characterized by a median particle size of 3.37±0.047 microns, a delivered dose of 75.16±0.16 %, a fine particle fraction of 54.7±0.37 %, and storage stability of at least 2 years.


Key words

naloxone, naltrexone, inhaler, dosage forms for inhalation.

Reference list

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Журнал основан 16 ноября 2000г.
Выдано Министерством РФ по делам печати, телерадиовещания и средств массовых коммуникаций

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