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Vol. 21, Art. 62 (pp. 757-767)    |    2020       

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Influence of peptide preparations on the course of acute severe ethanol poisoning in the experiment

Kirov Military Medical Academy Russian Federation Defense Ministry, Saint-Petersburg, Russia;
- Scientific Research Centre (Biological protection of special pur-pose) «48 Central scientific research institute»

Brief summary

Acute ethyl alcohol poisoning remains a frequent type of exogenous intoxication, which is characterized by a high level of lethality at the pre-hospital stage, which requires further de-velopment of effective therapeutic agents. The study is devoted to the experimental evaluation of the protective effectiveness of semax and molixan as part of mono-and complex therapy in the course of preventive and therapeutic regimens for acute ethanol intoxication in doses from 0,75 to 2,0 LD50 in rats. It was found that molixan, semax and their combination protected ethanol poisoned animals. The most optimal was the use of a combination of peptides, which increased the survival with the introduction of ethanol in doses up to 1.5 LD50.


Key words

poisoning, ethanol, molixan, semax, treatment.

Reference list

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References.


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2. Babanin A.A., Ulanov V.S. Analiz smertel'nyh otravlenij psihoaktiv-nymi veshchestvami v Respublike Krym za 1993?2017 / Sudebno-medicinskaya eksper-tiza. 2019. N 5. R. 54-57.


3. Bonitenko YU.YU., Livanov G.A., Bonitenko E.YU. et al. Ostrye otravleniya etanolom i ego surrogatami. SPb.: Elbi SPb., 2005. 225 r.


4. Buzanov D.V., Petrova N.V., Afanas'ev V.V. et al. Primenenie moliksana dlya rannego lecheniya alkogol'noj komy / Skoraya medicinskaya pomoshch'. 2016. N 4. R. 70-75. doi: 10.24884/2072-6716-2016-17-4-70-75


5. Bugaev P.A. Eksperimental'naya ocenka effektivnosti peptidnyh prepa-ratov pri porazheniyah pecheni proizvodnymi gidrazina. Avtoref. dis. - kand. med. nauk. SPb.: VMedA., 2019. 25 r.


6. Vinnikova M.A., Krenkel' N.T., Titkov M.S. et al. Inozin glicil-cisteinil-glutamat dinatriya (Moliksan?) v terapii tyazhelogo sindroma otmeny alko-golya: rezul'taty randomizirovannogo slepogo placebo-kontroliruemogo issledovaniya / Voprosy narkologii. 2019. T. 3, N 174. R. 48-63.


7. Golovko A.I. Otrezvlyayushchie sredstva, izmenyayushchie toksikodinamiku eta-nola / Biomedicinskaya himiya. 2013. T. 59, N 6. R. 604-622. doi: 10.18097/pbmc20135906604


8. Ostapenko YU.N., Kovalev A.V., Gasimova Z.M. et al. Toksikologicheskaya po-moshch' naseleniyu Rossijskoj Federacii: sostoyanie i problemy / Toksikologicheskij vest-nik. 2014. N 3. R. 2-8.


9. Halyutin D.A., Tarumov R.A., Hovpachev A.A. et al. Vliyanie peptidnyh pre-paratov na biohimicheskie pokazateli syvorotki krovi, golovnogo mozga i pecheni krys pri ostrom tyazhelom otravlenii etilovym spirtom / Toksikologicheskij vestnik. 2016. N 4. R. 28-25. doi: 10.36946/0869-7922-2016-4-28-35


10. Shabanov P.D. Psihofarmakologiya. SPb: Elbi-SPb, 2008. 416 r.


11. Kataria Y., Kellogg M.D. Acute alcohol toxicity / Clinical Chemistry. 2018. Vol. 64, N 12. P. 1788-1789. doi: 10.1373/clinchem.2018.293449


12. Vonghia L., Leggio L., Ferrulli A. et al. Acute alcohol intoxication / Eur. J. In-tern. Med. 2008. Vol. 19, N 8. P. 561-567. doi: 10.1016/j.ejim.2007.06.033

Журнал основан 16 ноября 2000г.
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