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Vol. 21, Art. 51 (pp. 620-629) | 2020
Neuromuscular transmission disorders following intoxications with sodium channel blockers: experimental study
State Scientific-research Test Institute of the Military Medicine, Russian Federation Defense Ministry, Saint-Petersburg, Russia.
Brief summary
The growing relevance of research of neurotoxins having biological origin is stipulated by expansions of freshwater reservoirs by cyanobacteria, accompanied by an increase in the incidence of alimentary poisoning of animals and people. Among the cyanobacteria neurotoxins in terms of toxicity, the most dangerous are substances from the group of sodium channel blockers (saxitoxins, tetrodotoxin). In order to improve the quality of diagnosis of poisoning by sodium channel blockers an experimental study of neural conduction and neuromuscular transmission disorders was performed using electromyography in an experimental model of an acute severe poisoning of rats with tetrodotoxin. It was found that the most characteristic electromyographic signs of severe tetrodotoxin poisoning are a progressive decrease in the amplitude and area of compound muscle potentials, as well as a rapid increase in their duration and latency in combination with a moderately pronounced decrement during rhythmic stimulation. Key words poisoning, sodium channel blockers, electromyography, tetrodotoxin, neurophysiology, diagnostics. (The article in PDF format. For preview need Adobe Acrobat Reader)  Open article in new window
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