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Федеральное государственное бюджетное учреждение науки
Институт теоретической и экспериментальной биофизики
Российской академии наук


ООО "ИЦ КОМКОН"

ФГБУН "Институт токсикологии" ФМБА России

Адрес редакции и реквизиты

192012, Санкт-Петербург, ул.Бабушкина, д.82 к.2, литера А, кв.378

Свидетельство о регистрации электронного периодического издания ЭЛ № ФС 77-37726 от 13.10.2009
Выдано - Роскомнадзор

ISSN 1999-6314


Фундаментальные исследования • Экспериментальная токсикология

Том: 21
Статья: « 63 »
Страницы:. 768-798
Опубликована в журнале: 21 мая 2020 г.
English version

Фаллоидиновый синдром: актуальные направления токсикокинетической и токсикодинамической терапии

Ховпачев А.А., Башарин В.А., Чепур С.В.

ФГБВОУ ВО «Военно-медицинская академия им. С.М. Кирова»
ФГБУ «Государственный научно-исследовательский испытательный институт
военной медицины» МО РФ


Резюме
Фаллоидиновый синдром представляет серьезную проблему вследствие частоты встречаемости, сложности диагностики и отсутствия эффективных средств специальной терапии и низкой выживаемости пациентов, в том числе после ургентной трансплантации печени. Прослежены особенности опосредованного аманитином токсического про-цесса и раскрыты взаимодействия всех групп токсинов в составе плодовых тел, которые могут играть большую роль в потенцировании токсичности аманитина, чем просто индукция гастроинтестинальных явлений. Рассмотрены преимущества и недостатки основных видов терапии, направленных на перераспределение аманитотоксинов в организме и их взаимодействие с основными рецепторами токсичности. Оценена роль средств, ингибирующих активность OATP1В3-переносчика и РНК-полимеразы II.


Ключевые слова
отравления, мицетизм, грибы, аманитин, полимиксин В, терапия.


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