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Федеральное государственное бюджетное учреждение науки
Институт теоретической и экспериментальной биофизики
Российской академии наук


ООО "ИЦ КОМКОН"

ФГБУН "Институт токсикологии" ФМБА России

Адрес редакции и реквизиты

192012, Санкт-Петербург, ул.Бабушкина, д.82 к.2, литера А, кв.378

Свидетельство о регистрации электронного периодического издания ЭЛ № ФС 77-37726 от 13.10.2009
Выдано - Роскомнадзор

ISSN 1999-6314


Фундаментальные исследования • Экспериментальная токсикология

Том: 21
Статья: « 54 »
Страницы:. 656-668
Опубликована в журнале: 21 мая 2020 г.
English version

Современное состояние и перспективы развития терапии острых отравлений токсальбуминами

Никишин А.С., Ильинский Н.С., Мясников В.А., Гоголевский А.С.

Федеральное государственное бюджетное учреждение «Государственный научно- исследовательский испытательный институт военной медицины» Министерства обороны Российской Федерации


Резюме
В работе представлен обзор современных подходов к лечению острых отравлений токсальбуминами на примере рицина. Отражены достижения в разработке средств неспецифической и специфической терапии. Определены перспективные направления в лечении острых интоксикаций, вызванных токсальбуминами, реализация которых может привести к снижению летальности.


Ключевые слова
токсальбумины, рицин, химическая безопасность, ранняя терапия, антитела


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Список литературы

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26. Gal Y. et al. Potent Antiedematous and Protective Effects of Ciprofloxacin in Pulmonary Ricinosis / Antimicrob Agents Chemother. 2016. Vol. 60. N 12. P. 7153-7158.


27. Beyer N.H. et al. A mous model for ricin poisoning and for evaluating protective effect of antiricin antibody / Clinic. Tox. 2009. Vol. 47. P. 219-225. doi: 10.1080/15563650802716521.


28. Pincus S.H. et al. Role of fc in antibody-mediated protection from ricin toxin / Toxins. 2014. Vol. 6. P. 1512-1525.


29. Sully E.K. et al. Chimeric plantibody passively protects mice against aerosolized ricin challenge / Clin. Vac. Immunol. 2014. Vol. 21. P. 777-782.


30. Prigent J. et al. Neutralising antibodies against ricin toxin / PLoS. 2011. Vol. 6. P. 315-324.


31. Noy-Porat T. et al. Isolation of Anti-Ricin Protective Antibodies Exhibiting High Affinity from Immunized Non-Human Primates / Toxin. 2016. Vol. 8. N 3. P. 64-79. doi: 10.3390/toxins8030064.


32. Hu W.G. et al. Conformation-dependent high-affinity potent ricin-neutralizing monoclonal antibodies / BioMed Res. Int. 2010. Vol. 185. N 1. P. 729-737.


33. Respaud R. et al. Development of a drug delivery system for efficient alveolar delivery of a neutralizing monoclonal antibody to treat pulmonary intoxication to ricin / J. Cont. Rel. 2016. Vol. 234. P. 21-32. doi: 10.1016/j.jconrel.2016.05.0


Reference





1. Roy C.J. et al. Animal models of ricin toxicosis / Curr. Top. Microbiol. Immunol. 2012. Vol. 357. P. 243-257. doi: 10.1007/82_2011_173.


2. Kaland M., Schwartz W., Anderson B. Toxalbumin exposures: 12 years' experience of U.S. poison centers / Toxicon. 2015. Vol. 99. P. 125-129.


3. Worbs S. et al. Ricinus communis intoxications in human and veterinary medicine - a summary of real cases / Toxins. 2011. Vol. 3. P. 1332-1372. doi: 10.3390/toxins3101332.


4. Roxas-Duncan V. I., Smith L.A. Of beans and beads: ricin and abrin in bioterrorism and biocrime / J. Bioterr. Biodef. 2011. Vol. 5. P. 1-20. doi: 10.4172/2157-2526.S2-002.


5. Supotnitsky M.S. The recognicion of damage by ricin. Prikladnaja toksikologia = Applied toxicology / 2013. Vol. 4. N. 1(9). P. 42-50 [In Russian].


6. Jackson L.S., Zhang Z., Tolleson W.H. Thermal stability of ricin in orange and apple juices / Journal of food science. 2010. Vol. 75. N 4. P. 65-71.


7. Zhang Z. et al. Thermal inactivation reaction rates for ricin are influenced by pH and carbohydrates / Food and chemical toxicology. 2013. Vol. 58. P. 116-123.


8. European Food Safety Authority (EFSA). Ricin (from Ricinus communis) as undesirable substances in animal feed‐Scientific Opinion of the Panel on Contaminants in the Food Chain / Efsa Journal. 2008. Vol. 6. N 9. P. 726.


9. Audi J. et al. Ricin poisoning. A comprehensive review / JAMA. 2005. Vol. 294. N 18. P. 2343-2351.


10. Hsiao Y.C., Ling Y.F, Weng K.L. Ricin and Abrin: A Comprehensive Review of Their Toxicity, Diagnosis, and Treatment / Toxinology. 2014. Vol. 15. N 7. P. 24-36. doi: 10.1007/978-94-007-6645-7_1-1.


11. Bhaskaran M. et al. Pathology of lethal and sublethal doses of aerosolized ricin in rhesus macaques / Toxicol. Pathol. 2014. Vol. 42. N 3. P. 573-581.


12. Leah G.D. Ricin Mechanism of Toxicity, Clinical Manifestation and Vaccine Development / J. of Toxicology. 2004. Vol. 42. N 2. P. 201-208.


13. Lombard S., Helmy M., Pieroni G. Lipolytic activity of ricin from Ricinus sanguineus and Ricinus communis on neutrallipids / Biochem. J. 2001. Vol. 358. N 3. P. 773-781.


14. Luzhnikov E. A. Medical toxicology: national guide. М.: GEOSTAR ─ Media, 2012. 928 p. [In Russian].


15. Kortepeter M. USAMRIID?s medical management of biological causalities. Maryland: Fort Detrick, 2001. 352 p.


16. Verougstrate N. et al. Lethal injection of a castor bean extract: ricinine quantification as a marker for ricin exposure using a validated LC-MS/MS method / J. Anal. Tox. 2019. Vol. 43. N 3. P. 1-5. doi: 10.1093/jat/bky100.


17. Assiri A. Ricin poisoning causing death after ingestion of herbal medicine / Ann. Saudi. Med. 2012. Vol. 32. N 3. P. 315-317.


18. Coopman V. et al. Suicidal death after injection of a castor bean extract (Ricinus communis L.) / Forensis. Sci. Int. 2009. Vol. 189. P. 13-20. doi: 10.1016/j.forsciint.2009.04.019.


19. Wang C.F. et al. Early plasma exchange for treating ricin toxicity in children after castor bean ingestion / J. Clin. Apher. 2015. Vol. 30. N 3. Р. 141-146. doi: 10.1002/jca.21351.


20. Wannemacher R. W., Anderson J. B. Inhalation ricin: aerosol procedures, toxicology and therapy / Inhalation toxicology. 2006. P. 973-980.


21. Dong N. et al. Monoclonal antibody, mAb 4C13, an effective detoxicant antibody against ricin poisoning / Vac. 2015. Vol. 33. N 32. P. 3836-3842. doi: 10.1016/j.vaccine.2015.06.096.


22. O?Hara J.M. et al. Plant-based expression of a partially humanized neutralizing monoclonal directed against an immunodominant epitope on the ricin toxin a subunit / Vac. 2012. Vol. 30. N 7. P. 1239-1243.


23. Gal Y. et al. Treatments for Pulmonary Ricin Intoxication: Current Aspects and Future Prospects / Toxin. 2017. Vol. 9. N 10. P. 311-325. doi: 10.3390/toxins9100311.


24. Whitfield S. et al. Production, Characterisation and Testing of an Ovine Antitoxin against Ricin; Efficacy, Potency and Mechanisms of Action / Toxins. 2017. Vol. 9. N 10. P. 10-18.


25. Gal Y. et al. Antibody/doxycycline combined therapy for pulmonary ricinosis: Attenuation of inflammation improves survival of ricin-intoxicated mice / Toxicol.Rep. 2014. Vol. 1. P. 496-504. doi: 10.1016/j.toxrep.2014.07.013.


26. Gal Y. et al. Potent Antiedematous and Protective Effects of Ciprofloxacin in Pulmonary Ricinosis / Antimicrob Agents Chemother. 2016. Vol. 60. N 12. P. 7153-7158.


27. Beyer N.H. et al. A mous model for ricin poisoning and for evaluating protective effect of antiricin antibody / Clinic. Tox. 2009. Vol. 47. P. 219-225. doi: 10.1080/15563650802716521.


28. Pincus S.H. et al. Role of fc in antibody-mediated protection from ricin toxin / Toxins. 2014. Vol. 6. P. 1512-1525.


29. Sully E.K. et al. Chimeric plantibody passively protects mice against aerosolized ricin challenge / Clin. Vac. Immunol. 2014. Vol. 21. P. 777-782.


30. Prigent J. et al. Neutralising antibodies against ricin toxin / PLoS. 2011. Vol. 6. P. 315-324.


31. Noy-Porat T. et al. Isolation of Anti-Ricin Protective Antibodies Exhibiting High Affinity from Immunized Non-Human Primates / Toxin. 2016. Vol. 8. N 3. P. 64-79. doi: 10.3390/toxins8030064.


32. Hu W.G. et al. Conformation-dependent high-affinity potent ricin-neutralizing monoclonal antibodies / BioMed Res. Int. 2010. Vol. 185. N 1. P. 729-737.


33. Respaud R. et al. Development of a drug delivery system for efficient alveolar delivery of a neutralizing monoclonal antibody to treat pulmonary intoxication to ricin / J. Cont. Rel. 2016. Vol. 234. P. 21-32. doi: 10.1016/j.jconrel.2016.05.0