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Vol. 20, Art. 5 (pp. 44-53)    |    2019       

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The world's opioid crisis

Golovko A.I., Ivanov M.B., Rejniuk V.L., Ivnitsky J.J., Barinov V.A., Dolgo-Saburov V.B., Zacepin E.P.

"Institute of Toxicology" of Federal Medico-Biological Agency of Russia, 192019, Saint Petersburg, Russian Federation, ul Bekhtereva

Brief summary

In recent years, new designer drugs from the synthetic opioid group have emerged in illicit trafficking in many countries. This was accompanied by an increase in the drug use of the population and an increase in the number of overdoses, including fatal ones, among opium addicts. This phenomenon is called the world opioid crisis. The review on the example of the United States shows the features of this phenomenon, accompanied by massive fatal poisoning. A brief toxicological description of the synthetic opioids involved is given.


Key words

the world's opioid crisis, synthetic opioids, fatal overdoses.

Reference list

1. Veselovskaya, N.V. Narkotiki. Svoistva, deistvie, farmakokinetika, metabolizm / N.V. Veselovskaya, A.E. Kovalenko. - M.: Triada-H, 2000. - 206 s.


2. Melentev, K. Metabolizm dizainerskih narkotikov. Proizvodnie fentanila / K. Melentev, K. Kataev // Sydebno-medicinskaya ekspertiza. - 2015. - T. 58, N 5. - S. 39-46.


3. Pogosov, A.V. Opiinie narkomanii: istoriya ycheniya, etnokyltyralnie aspekti, klinika, lechenie / A.V. Pogosov, P.K. Mystafetova. - M.: Belie alvi, 1998. - 192 s.


4. Armenian, P. Fentanyl, fentanyl analogs and novel synthetic opioids: A comprehensive review / P. Armenian, K.T. Vo, J. Barr-Walker, K.L. Lynch // Neuropharmacology. - 2018. - Vol. 134, Pt A. - P. 121-132.


5. Cole, J.B. Controversies and carfentanil: We have much to learn about the present state of opioid poisoning / J.B. Cole, L.S. Nelson // Am. J. Emerg. Med. - 2017. - Vol. 35, N 11. - P. 1743-1745.


6. Cox, B.M. Challenges for opioid receptor nomenclature: IUPHAR Review 9 / B.M. Cox, M.J. Christie, L. Devi, L. Toll, J.R. Traynor // Br. J. Pharmacol. - 2015. - Vol. 172, N 2. - P. 317-323.


7. Critical Review Report Agenda item 5.1 Expert Committee on Drug Dependence Thirty-seventh Meeting Geneva, 16-20 November 2015. - 20 p. - Rejim dostypa: http//www.who.int/medicines/access/controlled-substances/5.1_MT-45_CRev.pdf , svobodnii.


8. Dhawan, B.N. International Union of Pharmacology. XII. Classification of opioid receptors / B.N. Dhawan, F. Cesselin, R. Raghubir, T. Reisine, P.B. Bradley, P.S. Portoghese, M. Hamon // Pharmacol. Rev. - 1996. - Vol. 48, N 4. - P. 567-592.


9. EMCDDA-Europol 2017 Annual Report on the implementation of Council Decision 2005/387/JHA. - 31 p. - Rejim dostypa: http//www.emcdda.europa.eu/system/files/publications/9282/20183924_TDAN18001ENN_PDF.pdf, svobodnii.


10. EMCDDA-Europol 2009 Annual Report on the implementation of Council Decision 2005/387/JHA. - 25 p. - Rejim dostypa: http//www.emcdda.europa.eu/system/files/publications/553/2009_Implementation_report_281420.pdf, svobodnii.


11. European Monitoring Centre for Drugs and Drug Addiction (2018). European Drug Report 2018: Trends and Developments, Publications Office of the European Union, Luxembourg. - 96 p. - Rejim dostypa: http// www.emcdda.europa.eu/system/files/publications/8585/20181816_TDAT18001ENN_PDF.pdf, svobodnii.


12. European Monitoring Centre for Drugs and Drug Addiction (2018). Fentanils and synthetic cannabinoids: driving greater complexity into the drug situation. An update from the EU Early Warning System (June 2018), Publications Office of the European Union, Luxembourg. - 28 p. - Rejim dostypa: http// www.emcdda.europa.eu/system/files/publications/8870/2018-2489-td0118414enn.pdf , svobodnii.


13. Fentanyl and its analogues - 50 years on (2017). - 12 p. - Rejim dostypa: http// www.unodc.org/documents/scientific/Global_SMART_Update_17_web.pdf, svobodnii.


14. Henderson, G.L. Designer drugs: past history and future prospects / G.L. Henderson // J. Forensic Sci. - 1988. - Vol. 33, N 2. - P. 569-575.


15. Holden, J.E. The endogenous opioid system and clinical pain management / J.E. Holden, Y. Jeong, J.M. Forrest // AACN Clin. Issues. - 2005. - Vol. 16, N 3. - P. 291-301.


16. Katselou, M. A "krokodil" emerges from the murky waters of addiction. Abuse trends of an old drug / M. Katselou, I. Papoutsis, P. Nikolaou, C. Spiliopoulou, S. Athanaselis // Life Sci. - 2014. - Vol. 102, N 2. - P. 81-87.


17. Katselou, M. AH-7921: the list of new psychoactive opioids is expanded / M. Katselou, I. Papoutsis, P. Nikolaou, C. Spiliopoulou, S. Athanaselis // Forensic Toxicol. - 2015. - Vol. 33, N 2. - P. 195-201.


18. Logan, B.K. Reports of adverse events associated with use of novel psychoactive substances, 2013-2016: A review / B.K. Logan, A.L.A. Mohr, M. Friscia, A.J. Krotulski, D.M. Papsun, S.L. Kacinko, J.D. Ropero-Miller, M.A. Huestis // J. Anal. Toxicol. - 2017. - Vol. 41, N 7. - P. 573-610.


19. Misailidi, N. Fentanyls continue to replace heroin in the drug arena: the cases of ocfentanil and carfentanil / N. Misailidi, I. Papoutsis, P. Nikolaou, A. Dona, C. Spiliopoulou, S. Athanaselis // Forensic Toxicol. - 2018. - Vol. 36, N 1. - P. 12-32.


20. Mounteney, J. Fentanyls: Are we missing the signs? Highly potent and on the rise in Europe / J. Mounteney, I. Giraudon, G. Denissov, P. Griffiths // Int. J. Drug Policy. - 2015. - Vol. 26, N 7. - P. 626-631.


21. Nikolaou, P. U-47700. An old opioid becomes a recent danger / P. Nikolaou, M. Katselou, I. Papoutsis, C. Spiliopoulou, S. Athanaselis // Forensic Toxicol. - 2017. - Vol. 35, N 1. - P. 11-19.


22. Nolan, S. The threat of an international opioid crisis / S. Nolan, M.E. Socias, E. Wood // Current Addiction Reports. - 2018. - Vol. 5, N 4. - P. 473-477.


23. O Donnell, J.K. Trends in deaths involving heroin and synthetic opioids excluding methadone, and law enforcement drug product reports, by census region - United States, 2006-2015 / J.K. O Donnell, R.M. Gladden, P. Seth // MMWR Morb. Mortal. Wkly Rep. - 2017. - Vol. 66, N 34. - P. 897-903.


24. Overdose death rates. National Institute on Drug Abuse. - Rejim dostypa: http// www.oxfordtreatment.com/fentanyl/lethal-dose/, svobodnii.


25. Pichini, S. Acute intoxications and fatalities from illicit fentanyl and analogues: An update / S. Pichini, R. Solimini, P. Berretta, R. Pacifici, F.P. Busardò // Ther. Drug Monit. - 2018. - Vol. 40, N 1. - P. 38-51.


26. Prekupec, M.P. Misuse of novel synthetic opioids: A deadly new trend / M.P. Prekupec, P.A. Mansky, M.H. Baumann // J. Addict. Med. - 2017. - Vol. 11, N 4. - P. 256-265.


27. Recommended methods for the identification and analysis of fentanyl and its analogues in biological specimens. Manual for use by National drug analysis laboratories. UNODC (2017). - 72 p. - Rejim dostypa: http// www.unodc.org/documents/scientific/Recommended_methods_for_the_identification_and_analysis_of_Fentanyl.pdf, svobodnii.


28. Rudd, R.A. Increases in drug and opioid-involved overdose deaths - United States, 2010-2015 / R.A. Rudd, P. Seth, F. David, L. Scholl // MMWR Morb. Mortal. Wkly Rep. - 2016. - Vol. 65, N 50-51. - P. 1445-1452.


29. Schug, S.A. Fentanyl formulations in the management of pain: An update / S.A. Schug, S. Ting // Drugs. - 2017. - Vol. 77, N 7. - P. 747-763.


30. Singh, V.K. Molecular biology of opioid receptors: recent advances / V.K. Singh, K. Bajpai, S. Biswas, W. Haq, M.Y. Khan, K.B. Mathur // Neuroimmunomodulation. - 1997. - Vol. 4, N 5-6. - P. 285-297.


31. Solimini, R. Pharmacotoxicology of non-fentanyl derived new synthetic opioids / R. Solimini, S. Pichini, R. Pacifici, F.P. Busardò, R. Giorgetti // Front. Pharmacol. - 2018. - Vol. 9. - Article 654. - 8 p. - Rejim dostypa: http// www.ncbi.nlm.nih.gov/pmc/articles/PMC6020781/pdf/fphar-09-00654.pdf, svobodnii.


32. Suzuki, J. A review: Fentanyl and non-pharmaceutical fentanyls / J. Suzuki, S. El-Haddad // Drug Alcohol Depend. - 2017. - Vol. 171. - P. 107-116.


33. Ujváry, I. Acryloylfentanyl, a recently emerged new psychoactive substance: a comprehensive review / I. Ujváry, R. Jorge, R. Christie, T. Le Ruez, H.V. Danielsson, R. Kronstrand, S. Elliott, A. Gallegos, R. Sedefov, M. Evans-Brown // Forensic Toxicol. - 2017. - Vol. 35, N 2. - P. 232-243.


34. Vadivelu, N. The opioid crisis: a comprehensive overview / N. Vadivelu, A.M. Kai, V. Kodumudi, J. Sramcik, A.D. Kaye // Curr. Pain Headache Rep. - 2018. - Vol. 22, N 3. - Article 16. - 6 p. - Rejim dostypa: http//link.springer.com/article/10.1007%2Fs11916-018-0670-z, svobodnii.

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