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 УЧРЕДИТЕЛИ:
Институт теоретической и экспериментальной биофизики Российской академии наук.

ООО "ИЦ КОМКОН"

ФГБУН "Институт токсикологии" ФМБА России




Адрес редакции и реквизиты

192012, Санкт-Петербург, ул.Бабушкина, д.82 к.2, литера А, кв.378

Свидетельство о регистрации электронного периодического издания ЭЛ № ФС 77-37726 от 13.10.2009
Выдано - Роскомнадзор

ISSN 1999-6314

Российская поисковая система
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«
Vol. 19, Art. 9 (pp. 117-130)    |    2018       
»

Determination of antithrombotic activity of methylthiazole-and triazole-containing PPAR delta / beta agonists
Minin D.V., Popkov S.V., Burdeinyi M.L., Mantrov S.N., Goncharov V.M.,
Vasilevsky S.V.

D. Mendeleev University of Chemical Technology of Russia



Brief summary

The antithrombotic activity of five synthesized PPAR delta / beta agonists (2-methyl-4-[4-methyl-2-(4-trifluoromethylphenyl)-1,3-thiazole-5-ilmethylthio]-phenoxy)acetic acid was investigated as well as its two metabolites and two triazole analogues by measuring platelet aggregation in platelet-rich plasma. It was established that the sulfonic derivative of methylthiazole-containing acid has the highest antithrombotic activity.


Key words

PPAR agonists, antithrombotic activity, (2-methyl-4-[4-methyl-2-(4-trifluoromethylphenyl)-1,3-thiazole-5-ilmethylthio]-phenoxy)acetic acid, peroxisome proliferator-activated receptors, PPAR delta / beta





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