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Vol. 18, Art. 22 (pp. 313-321) | 2017
Genetic markers and biochemical characteristics of the comorbidity in patients with severe hemophilia, associated with oxidative stress
Kargin V.D., Soldatenkov V.E., Kapustin S.I., Chechetkin A.V., Bessmeltsev S.S., Burakov V.V., Rybakova L.P., Aleksanyan L.R., Shmeleva V.M., Smirnova O.A., Papayan L.P., Titov A.G., Komissarov K.A.
Russian Research Institute of Hematology and Transfusiology, St-Petersburg, Russia
Brief summary
The results of the study of comorbidity in patients with severe hemophilia, associated with metabolic disorders of homocysteine and expression of oxidative aggression, are presented. The frequency of hyperhomocysteinemia as an inducer of oxidative stress, as well as condition of lipid peroxidation and antioxidative protection, involved in the progression of joint disease in patients with hemophilia, have been studied. Based on genetic and biochemical data, the origin of hyperhomocysteintmia and oxidative disorders and their role in comorbidity in patients with severe hemophilia has been established, as well as the predictors of those disorders were identified. Key words hemophilia, genetic, prognostic factor, hyperhomocysteintmia, comorbidity (The article in PDF format. For preview need Adobe Acrobat Reader)  Open article in new window
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