FGUP "Scientific Center "Signal", Moscow, ul. Bolshaya Olenya, 8
Brief summary
Self-emulsifying systems were obtained, data of its physicochemical properties were presented and potential of its application for oral delivery of insulin were considered. Resistance of insulin self-emulsifying systems for gastric fluid degradation in vitro was studied and bioavailability of insulin in its systems in vivo was researched.
Key words
nanoemulsion, self-emulsifying drug delivery systems, oral delivery, bioavailability, insulin.
1. Katteboina S., Chandrasekhar P., Balaji S. Approaches for the development of solid self-emulsifying drug delivery systems and dosage forms. // Asian J. Pharm. Sci. 2009. Vol. 4, N 4.
R. 240-253.
2. Siekmeier R., Scheuch G. Inhaled insulin - does it become reality? // J. Physiol. Pharmacol. 2008. Vol. 59, Suppl. 6. R. 81-113.
3. Duckworth W.C. Insulin degradation: mechanisms, products, and significance. // Endocrine Rev. 1988. Vol. 9, N 3. R. 319-345.
4. Saffran M., Kumar G.S., Savariar C., Burnham J.C., Williams F., Neckers D.C. A new approach to the oral administration of insulin and other peptide drugs. // Science. 1986. New Series. Vol. 233, N 4768. R. 1081-1084.
5. Bhumkar D.R., Joshi H.M., Sastry M., Pokharkar V.B. Chitosan reduced gold nanoparticles as novel carriers for transmucosal delivery of insulin. // Pharm. Res. 2007. Vol. 24, N 8. R.?1415-1426.
6. Heinemann L. New ways of insulin delivery. // Int. J. Clin. Pract. 2012. Vol. 66, Suppl. 175. R.?35-39.
7. Verma A., Kumar N., Malviya R., Sharma P.K. Emerging trends in noninvasive insulin delivery. // J. Pharm. Vol. 2014. R.?1-9.
8. Yamamoto A., Taniguchi T., Rikyuu K., Tsuji T., Fujita T., Murakami M., Muranishi S. Effects of various protease inhibitors on the intestinal absorption and degradation of insulin in rats. // Pharm. Res. 1994. Vol. 11, N10. R. 1496-1500.
9. Çilek A., Çelebi N., Tirnaksiz F., Tay A. A lecithin-based microemulsion of rh-insulin with aprotinin for oral administration: Investigation of hypoglycemic effects innon-diabetic and STZ-induced diabetic rats. // Int. J. Pharm. 2005. Vol. 298. R. 176-185.
10. Silva-Cunha A., Chéron M., Grossiord J.L., Puisieux F., Seiller M. W/O/W multiple emulsions of insulin containing a protease inhibitor and an absorption enhancer: biological activity afteroral administration to normal and diabetic rats. // Int. J. Pharm. 1998. Vol. 169. R.?33-44.
11. Morishita M., Kajita M., Suzuki A., Takayama K., Chiba Y., Tokiwa S., Nagai T. The dose-related hypoglycemic effects of insulin emulsions in corporating highly purified EPA and DHA. // Int. J. Pharm. 2000. Vol. 201. R. 175-185.
12. Shichiri M., Shimizu Y., Yoshida Y., Kawamori R., Fukuchi M., Shigeta Y., Abe H. Enteral absorption of water-in-oil-in-water insulin emulsions in rabbits. // Diabetologia. 1974. Vol. 10. R. 317-321.
13. Cho Y.W., Flynn M. Oral delivery of insulin. // Lancet. 1989. R. 1518-1519.
14. MacGregor K.J., Embleton J.K., Lacy J.E., Perry E.A., Solomon L.J., Seager H., Pouton?C.W. Influence of lipolysis on drug absorption from the gastro-intestinal tract. // Adv. Drug Delivery Rev. 1997. Vol. 25. R. 33-46.
15. Lawrence M.J., Rees G.D. Microemulsion-based media as novel drug delivery systems.
// Adv. Drug Delivery Rev. 2000. Vol. 45. R. 89-121.
16. Alekseev K.V., Tyrchinskaya K.G., Blinskaya E.V., Tihonova N.V. Tehnologiya samoemylgiryushihsya sistem dostavki lekarstvennih veshestv. // Vestn. novih med. tehnol. 2014. T. 21, N1. S.128-133.