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 УЧРЕДИТЕЛИ:
Институт теоретической и экспериментальной биофизики Российской академии наук.

ООО "ИЦ КОМКОН"

ФГБУН "Институт токсикологии" ФМБА России




Адрес редакции и реквизиты

192012, Санкт-Петербург, ул.Бабушкина, д.82 к.2, литера А, кв.378

Свидетельство о регистрации электронного периодического издания ЭЛ № ФС 77-37726 от 13.10.2009
Выдано - Роскомнадзор

ISSN 1999-6314

Российская поисковая система
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«
Vol. 16, Art. 77 (pp. 850-871)    |    2015       
»

Evaluation of effectiveness of a non-hormonal succinate-based composition on the levels of estradiol, follicle-stimulating and luteinizing hormones in women's blood during menopause
Е.I. Maevsky

The Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences»



Brief summary

The repeated statistical analysis of the primary digital data from the previous placebo-controlled clinical study on the effects of a succinate-containing composition on the climacteric syndrome was carried out. Nonparametric statistics were significantly more informative than the previously used parametric Student's t-test, since there was no normal distribution in the obtained samples. Among the most informative was paired sign test. In addition to the previously observed increase in estradiol levels, we observed a statistically significant increase in the concentrations of LH and FSH. It was found that the correction of climacteric syndrome with the metabolic composition has not disturbed the physiological ratios between these hormones. In the experimental and control groups, higher levels of estradiol corresponded to lower concentrations of FSH and LH in the blood. Impact of the metabolic composition on the hormonal and psycho-emotional status of women depended on the initial hormonal and psycho-emotional state before the metabolic correction. The effects of metabolic composition were more pronounced when initial blood estradiol levels were low. In the absence of normal distributions in the samples of the analyzed clinical data, a standard use of parametric criteria masked the real picture and led to incorrect conclusions.


Key words

Climacteric syndrome. metabolite correction, estradiol, follicle stimulating hormone, luteinizing hormone, effectiveness of nonparametric statistics.





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Reference list

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