The poisoning and ways to solve it problem of the “golden hour” in the pharmacotherapy of acute
Ivnitsky J. J., Krasnov K. A., Rejniuk V. L., Schäfer T. V.
Federal State Institution of Science "Institute of Toxicology, Federal Medical-Biological Agency"
Military-Medical Academy. SM Kirov
Brief summary
The subject of the survey is the rationale for the suggestions of the improving the first aid and medical care in acute poisoning of staff of the armed forces. The effectiveness of systemically acting pharmaceuticals at a prehospital stage is limited by the discrepancy of their dosage forms and demands of first aid, emergency care and emergency physician’s care. The relevance of dosage forms used in military medical service link under these circumstances is analysed. Revealed are the perspectives of a new dosage form, a so named transdermal spray, at a prehospital stage of the treatment of acute poisonings. Formulated is the core principle of the suitability of pharmaceuticals to the application in the form of a transdermal spray.
Key words
acute poisoning, first aid, pharmaceutical, dosage form, transdermal spray.
1. Antidotnaya terapiya otravlenii visokotoksichnimi veshestvami v ysloviyah chrezvichainih sityacii: rykovodstvo / Pod red. V. D. Gladkih, S. H. Sarmanaeva, U. N. Ostapenko // FMBA. — M: Kommentarii, 2014. — 272 s.
2. Bonitenko E. U., Bonitenko U. U., Byshyev E. S. i dr. Ostrie otravleniya lekarstvennimi sredstvami i narkoticheskimi veshestvami. — SPb.: ELBI-SPb, 2010. — 440 s.
3. Voenno-polevaya terapiya: nacionalnoe rykovodstvo / Pod red. I. U. Bikova, A. L. Rakova, A. E. Sosukina. — M.: GEOTAR-Media, 2007. — 416 s.
4. Instrykciya po soderjaniu i ispolzovaniu aptechek pervoi pomoshi, shkafov ekstrennoi i neotlojnoi medicinskoi pomoshi v voinskih chastyah i organizaciyah Vooryjyonnih Sil Rossiiskoi Federacii / Ytv. nachalnikom GVMY MO RF 4 iulya 2014 g. — M.: GVMY, 2014. — 76 s.
5. Kompoziciya dlya transdermalnoi dostavki v organizm lekarstvennih veshestv i lekarstvennaya forma na eyo osnove: pat. 2535095 Rossiiskaya Federaciya, MPK S2 A61K 9/06 A61K 9/12 A61K 47/22 A61K 47/16 / U. U. Ivnickii, K. A. Krasnov, T. V. Shefer; FGBYN «Instityt toksikologii FMBA». — № 2013102458/15; zayavl. 09.01.2013; opybl. 10.12.2014, Bul. № 34. — 20 s.
6. Mashkovskii M. D. Lekarstvennie sredstva. Posobie dlya vrachei. — M.: Novaya Volna, 2012. — 1216 s.
7. Medicinskaya toksikologiya: nacionalnoe rykovodstvo / Pod red. E. A. Lyjnikova. — M.: GEOTAR-Media, 2012. — 928 s.
8. Ob obrashenii lekarstvennih sredstv: Federalnii zakon RF ot 12 aprelya 2010 g. № 61-FZ.
9. Ob ytverjdenii sbornika opisei komplektov medicinskogo imyshestva dlya voiskovogo zvena medicinskoi slyjbi Vooryjyonnih Sil Rossiiskoi Federacii na voennoe vremya: prikaz nachalnika GVMY MO RF ot 12 iulya 2011 g. № 77. — SPb., 2011. — 332 s.
10. Ostapenko U. N. Antidotnaya terapiya ostrih otravlenii na dogospitalnom etape // MedlineRu, 2004. — T. 5. — S. 55—64.
12. Ykazaniya po voennoi toksikologii. — M.: GVKG im. N.N. Byrdenko, 2000. — 299 s.
13. Marquis M. Da Shock Tramatique dans les blessures de Guerre, Analysis d'observations // Bull. Med. Soc. Chir., 1918. — Vol. 44. — P. 205.
14. Marwah H., Garg T., Goyal A.K., Rath G. Permeation enchancer strategies in transdermal drug delivery // Drug Deliv. — 2014. — 15 p. — Url: http://informahealthcare.com/doi/pdf/10.3109/10717544.2014.935532 (Data obrasheniya 4 yanvarya 2015 g.).
15. Textbook of military medicine. Medical aspects of chemical and biological warfare / Ed. R. Zaitchuk. — Bethesda: University of the health Sciences, 1997. — 370 p.