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Vol. 16, Art. 50 (pp. 542-559)    |    2015       

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Neurofunctional alterations in patients with opioid addiction: functional mri data.

Litvintsev B.S., Efimtsev A.Y., Tarumov D.A., Fokin V.A., Trufanov G.E., Konstantiov D.P., Petrov A.D.

Military Medical Academy. S.M. Kirov, 194044, St. Petersburg, Akademika Lebedeva str. 6.
+7(812)292-33-47
rentgenvma@mail.ru

Brief summary

Here are the results of functional MRI of addictive disorders among drug dependent patients using clinical, laboratory and instrumental techniques. Functional MRI data revealed that patients with opioid addiction, compared to healthy individuals have got functional changes in the occipital region, the prefrontal cortical areas, hippocampus, basal ganglia. At the same time, there were no signs of organic brain lesions in these patients. Though, all of them met high levels of reactive anxiety, suicide risk, depression, neurological symptoms that revealed evidence of diffuse nature of the nervous system lesion.


Key words

addictive disorders, opioid addiction, Functional magnetic resonance imaging.

Reference list

1. Bysheneva, S.N. Sovremennie vozmojnosti issledovaniya fynkcionirovaniya i reorganizacii mozgovih stryktyr / S.N. Bysheneva, A.S. Kadikov, M.V. Krotenkova // Nevrol. jyrnal. – 2007. – №3. – S. 37 – 41.


2. Vorobev, S.V. Patogeneticheskie osobennosti kognitivnih naryshenii pri posttravmaticheskoi encefalopatii po rezyltatam dannih fynkcionalnoi magnitno-rezonansnoi tomografii / S.V. Vorobev, V.A. Fokin, A.U. Emelin [i dr.] // Vestn. Ros. Voen.-med. akademii. – 2014. - №1 (45). – S. 29-34.


3. Geht, A.B. Nevrologicheskie narysheniya y bolnih geroinovoi narkomaniei pri ostroi abstinencii i v rannem postabstinentnom periode / A.B. Geht, E.I. Gysev, A.G. Polynina, E.A. Brun // Jyrn. nevrol. i psihiatr. – 2003. – T. 103, №2. – S. 9-15.


4. Golovko, A.I. Viyavlenie «narkotikov iznasilovaniya» v biologicheskih sredah jertv seksyalnogo nasiliya / A.I. Golovko, L.V. Leonteva, V.A. Barinov [i dr.] // Medlain.ru. – 2013. – T. 14, St. 57. – S. 706 – 725.


5. Litvinenko, I.V. Cerebralnie sosydistie izmeneniya pri bolezni Parkinsona: neirovizyalizacionnie patogeneticheskie varianti / I.V. Litvinenko, A.A. Saharovskaya, M.M. Odinak // Nevrol. jyrnal. – 2010. - №3. – S. 25-34.


6. Mendelevich, V.D. Narkozavisimost kak medicinskaya problema / V.D. Mendelevich // Vestnik epileptologii. – 2008. - №2. – s. 7-10.


7. Rohlina, M.L. Narkomanii. Toksikomanii: psihicheskie rasstroistva i rasstroistva povedeniya, svyazannie s ypotrebleniem psihoaktivnih veshestv / M.L. Rohlina. – M.: Littera, 2010. – 256 s.


8. Trofimova, T.N. Lychevaya diagnostika toksicheskih porajenii golovnogo mozga / T.N. Trofimova, G.A. Safronov, N.A. Belyakov, S.V. Medvedev // Lychevaya diagnostika i terapiya. – 2011. - №1 (2). – S. 37-46.


9. Fashytdinova, G.G. Molekylyarno-geneticheskie aspekti zavisimosti ot psihoaktivnih veshestv / G.G. Fashytdinova, D.A. Gaisina, S.S. Kylichkin, E.K. Fysnytdinova // Medicinskaya genetika. – 2007. – T.6, №7 (61). – S. 3-11.


10. Shabanov, P.D. Narkologiya: rykovodstvo dlya vrachei / P.D. Shabanov. – M.: GEOTAR-Media, 2012. – 832 s.


11. Shamrei, V.K. Neirovizyalizacionnaya diagnostika depressivnih rasstroistv / V.K. Shamrei, E.U. Abritalin, D.A. Tarymov, A.V. Korzenev. – SPb.: «Nayka», 2013. – 115 s.


12. Filbey, F.M. Marijuana craving in the brain / F.M. Filbey, J.P. Schacht, U.S. Maers [et al.] // PNAS. – 2009. – Vol. 106 (31). – P. 13016-13021.


13. Goldstein, R.Z. Dopaminergic response to drug words in cocaine addiction / R.Z. Goldstein, D. Tomasi, N. Alia-Klin [et al.] // Neuroscience. – 2009. – V.29, N 18. – P. 6001-6006


14. Goldstein, R.Z. Role of the anterior cingulate and medial orbitofrontal cortex in progressing drug cues in cocaine addiction / R.Z. Goldstein, D. Tomasi, S. Rajaram [et al.] // Neuroscience. – 2007. – Vol. 144. – P. 1153-1159.


15. Guyer, S. Pattern of regional cerebral blood-flow changes induced by acute heroin administration – a perfusion MRI study / S. Guyer, M. Kosel, S. Altrichter [et al.] // Jour. of neurorad. – 2007. – Vol. 34, N 5. – P. 322-329.


16. Liu, J. Disfunctional connectivity patterns in chronic heroin users / J. Liu, J. Liang, W. Qin [et al.] // Neuroscience Letters. – 2009. – V.460. – P. 72-77.


17. Nutt, J.D. Addiction / J.D. Nutt, L.J. Nestor. – Oxford University Press, 2013. – 89 p.


18. Smoski, M.J. Functional imaging of emotion reactivity in opiate-dependent borderline personality disorder / M.J. Smoski, N. Salsman, L. Wang [et al.] // Pers. Dis. – 2011. – Vol. 2, N 3. – P. 230-241.


19. Sutherland, M.T. Resting state functional connectivity in addiction: Lessons learned and a road ahead / M.T. Sutherland, M.J. McHugh, V. Pariyadath, E.A. Stein // Neuroimage. – 2012. – Vol. 62. – P. 2281-2295.

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