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Медико-биологический
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Vol. 15, Art. 22 (pp. 238-249) | 2014
Factors of circadian dynamics individualization of the liver metabolic activity in guinea pigs under acute toxic effects
Novochadov V.V., Shatyr Y.A. , Kudryavtseva G.A., Mulik A.B.
Volgograd State University
Brief summary
Under conditions of acute toxic exposure (lipopolysaccharide S. Thyphimurium) is defined the specificity of circadian dynamics of the liver metabolic activity in guinea pigs with different levels of general non-specific reactivity of the organism. Characterized expression of lipid’s growth and products of their peroxidation, as well as the degree of reduction of intermediate metabolism’s enzyme activity in the liver after the introduction of bacterial lipopolysaccharide at different times of day. Key words toxic effects, liver metabolism, the level of general non-specific reactivity, circadian biorhythms, individualization of homeostasis. (The article in PDF format. For preview need Adobe Acrobat Reader)  Open article in new window
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