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Vol. 14, Art. 79 (pp. 993-1007)    |    2013       

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The genetic factors, which define the different action’s effects of ethanol for an organism

Osechkina N.S., Nazarov G.V., Bonitenko E.J., Ivanov M.B., Kashuro V.A., Lapina N.V. Babkin A.V., Berdinskih I.S.

Federal State Scientific Institution «Institute of Toxicology Federal Medico-Biological Agency»

Brief summary

In the review are examined the genetic factors, which define the different action’s effects of ethanol for an organism. We’re talking about the meaning of genes which encode ethanol metabolism\'s ferments and receptors for neurotransmitters. Here were examined the polymorphisms genes, their level of expression as an association with risk of various pathological organism’s conditions. After analyzing the data this review we may make a conclusion more likely that reaction of the organism under the ethanol influence are determined genetically. Research for topical areas should include search connection the genetic characteristics with variability of the organism\'s response in acute ethanol intoxication.


Key words

ethanol, gene, polymorphism, expression, neurotransmitter, alcohol dependence, tolerance, intoxication.

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