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Медико-биологический
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Vol. 12, Art. 109 (pp. 1342-1349) | 2011
The experimental substantiation of the emergency exposure limits of soman for the air of the working place
Kuznetsova E.A., Zhukov V.E., Kolodii T.I.
Research Institute of Hygiene, Toxicology and Occupational Pathology of Federal Medical and Biological Agency of Russia
Brief summary
To substantiate emergency exposure limits of soman the toxicological parameters of substance: median lethal concentration (CL50), threshold of specific toxic effect (Limac.sp.), threshold of general toxic effect (Limac.integr.) were defined in the experiment with the exposures that lasted for 30 min., 1, 2, 4 hours. The dependence “concentration- time- effect” was revealed as the result of the inhalation of soman. The data were used for the development of the emergency exposure limits of soman in the air of the working place and the mathematical forecasting of the mentioned limits in the interval from 18 minutes to 5 hours. Key words Soman, emergency exposure limits, working place, inhalation. (The article in PDF format. For preview need Adobe Acrobat Reader)  Open article in new window
Reference list 1. Razrabotka i obosnovanie avariinih predelov vozdeistviya visokotoksichnih himicheskih soedinenii - otravlyaushih veshestv (OV) i komponentov raketnih topliv (KRT), MY 2.1.781-99. 2. Shkodich, P.E. Ekologo-gigienicheskie aspekti problemi ynichtojeniya himicheskogo oryjiya / P.E. Shkodich, V.F. Jeltobruhov, V.V. Klaychek. - Volgograd, 2004. - 235 s. 3. Metodicheskie ykazaniya k postanovke issledovanii dlya obosnovaniya sanitarnih standartov vrednih veshestv v vozdyhe rabochei zoni. Ytv. Glavnim gosydarstvennim sanitarnim vrachom SSSR 4 aprelya 1980 g. №2163-80. 4. Metodika vipolneniya izmerenii massovoi koncentracii zomana v vozdyhe rabochei zoni fermentativnim metodom № 031-01-017-06 ot 29.11.2006 g. 5. Panukov, A.N. O primenenii metoda Hestrina dlya razdelnogo izmereniya aktivnosti holinesteraz / A.N. Panukov // Voprosi Medicinskoi himii.- T.12, vip. 1. - 1966. - S.88-95 6. Kozlovskaya, L.V. Ychebnoe posobie po klinicheskim laboratornim metodam issledovaniya / L.V. Kozlovskaya, M.A. Martinova. - 1975. - 352 s. 7. Trahtenberg, I.M. Metodi izycheniya toksicheskogo deistviya himicheskih i biologicheskih zagryaznitelei / I.M. Trahtenberg, L.A. Timofeevskaya, I.Ya. Kvyatkovskaya. - Riga: Znanie, 1987. - 172 s. 8. Bokyneva, N.I. Spravochnik po klinicheskim laboratornim medicinskim issledovaniyam / N.I. Bokyneva [i dr.] - M.: Medicina, 1975. - 125 s. 9. Kolb, V.G. Spravochnik po klinicheskoi biohimii/ V.G. Kolb, V.S.Kamishnikov. – Minsk, 1982. - 198 s. 10. Pokrovskii, A.A. Biohimicheskie metodi issledovaniya v klinike/ A.A.Pokrovskii. - M.: Medgiz, 1969. - 503 s. 11. Rilova, M.P. Primenenie integralnih metodov issledovaniya dlya viyavleniya deistviya okisi ygleroda pri povtornih zatravkah / M.P. Rilova. - M.: Promishlennaya toksikologiya, 1960.- S. 264 - 270 12. Speranskii, S.I. O preimyshestvah ispolzovaniya narastaushego toka pri issledovanii sposobnosti belih mishei k symmacii podporogovih impylsov/ S.I. Speranskii // Farmakologiya i toksikologiya. - 1965. - №1. - S. 123-126 13. Merkylov, G.A. Kyrs patogistologicheskoi tehniki/ G.A. Merkylov - L.: Medicina,1969. - 339 c. 14. Belenkii, M.L. Elementi kolichestvennoi ocenki farmakologicheskogo effekta / M.L. Belenkii.- M.: Gos.izd.med.literatyri, 1963. - 152 s. 15. Merkov, A.M. Sanitarnaya statistika / A.M. Merkov, L.E. Polyakov. - L.: Medicina, 1974. - 387 s. 16. GOST 12.1.007-76*. SSBT. Vrednie veshestva. Klassifikaciya i obshie trebovaniya bezopasnosti. - Vved. 01.01.1997 - Postanovlenie Goskomstandarta SSSR ot 10.03.1976 g. № 579. - Pereizdan s izmeneniyami (IYS № 12-81 i № 6-1990). 17. Kalinina, N.I. K voprosy o standartah bezopasnosti pri ynichtojenii himicheskogo oryjiya / N.I. Kalinina // Toksikologicheskii vestnik. - 1994. - №3. - S. 6-9 18. Shkodich, P.E. Toksiko-gigienicheskie aspekti standartizacii avariinih sityacii pri ynichtojenii himicheskogo oryjiya / P.E. Shkodich, N.I. Kalinina // Rossiiskii himicheskii jyrnal. - 1993. - T. HHHVII, №3. - S. 79 - 82 19. Borovkov, A.A. Matematicheskaya statistika/ A.A. Borovkov.- M.: Nayka, 1984 |
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