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Медико-биологический
информационный портал
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для специалистов |
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Vol. 11, Art. 52 (pp. 611-634) | 2010
№ гос. регистрации: 0421000002 052
SOME MECHANISMS OF BIOENERGY DISORDERS AND OPTIMIZATION OF THE APPROACHES TO ITS PHARMACOTHERAPY
Federal State Scientific Institution «Institute of Toxicology» Federal Medico-Biological Agency, St. Petersburg, Russia
Brief summary
Kashuro V.A., Dolgo-Saburov V.B., Basharin V.A., Bonitenko E.Yu., Lapina N.V. The molecular mechanisms of energy supply disorders in the cells during hypoxia are considered. Deficiency of oxidized form NAD and increase NADН/NAD ratio lead to disruptions such as disorders of glycolysis, citric acid cycle, exchange of lipids and amino acids, activation of free-radical processes and apoptosis. The main directions of energy metabolism support therapy during hypoxia are formulated. Key words hypoxia, bioenergy metabolism, pharmacotherapy, mitochondria. (The article in PDF format. For preview need Adobe Acrobat Reader)  Open article in new window
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