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Медико-биологический
информационный портал
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для специалистов |
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Vol. 11, Art. 59 (pp. 718-735) | 2010
№ гос. регистрации: 0421000002 059
Algorithm of exaperimental modelling of the toxic coma at rats
Bonitenko E.Yu., Golovko A.I., Basharin V.A., Ivanov M.B., Petrov A.H., Makarova N.V.
Federal State Scientific Institution «Institute of Toxicology» Federal Medico-Biological Agency, St. Petersburg, Russia
Brief summary
The algorithm of experimental models creation of coma at deprimative agents intoxications with the different mechanisms of toxic action is represented. Assessment criteria of the neurological functions oppression severity, the degree of coma depth and outcome prediction of acute poisoning with ethanol, 1,4-butanediol, sodium thiopental and sodium oxybutyrate are developed. Model of toxic coma can be created for certain substances in the experiment. Key words toxic coma, experimental model, intoxication (The article in PDF format. For preview need Adobe Acrobat Reader)  Open article in new window
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