The effect of peptide preparation containing a fragment 4-10 of adrenocorticotropic hormone and delta sleep inducing peptide on he development offspring in the postnatal period
1FSBUN IT FMBA Federal State Budgetary Institution of Science «Institute of toxicology of the Federal medical-biological agency»
192019, Sankt-Peterburg, ul. Behtereva, d.1, telefon/faks: (812) 365-06-80.
2FSBNU NII MT Federal State Budgetary Science Institution «Scentific institute of occupational medicine named after academician N.F. Izmerova»
105275, Moskva, pr. Budennogo, d.31
3 FSBEI HE StPSCPU Federal State Budgetary Educational Institution of Hight Education «Sant-Petersburg State Chemical and Pharmaceutical University»
197022, Sankt-Peterburg, ul. Prof. Popova, d.14
Brief summary
The aim of the study was to assess the effect of delta-sleep inducing peptide (DSIP) and an analogue of the ACTH4-10 fragment (FACTG) on the postnatal development of the offspring of female non-inbred rats. The study was carried out in two stages. At the first stage, female rats received peptide preparations for 2 weeks, after which they mated with intact males. At the second stage, the parameters of physical and sensory-motor development were investigated in the newborn offspring using standard methods, and also behavioral reactions were studied in the "cruciform maze" test. For a comprehensive assessment of the development of offspring in the postnatal period, indices of physical and sensory-motor development were used, and the index of harmony of development was calculated. It was found that peptide preparations containing DSIP and 4-10 ACTH had a similar prolonged effect on the reproductive function of female rats, which was manifested by changes in the physical and sensory-motor development of their offspring; reduced the level of anxiety and improved adaptation to the new environment.
Key words
neuropeptides, fragment 4-10 of adrenocorticotropic hormone, delta sleep inducing peptide, physical development offspring, sensory-motor development offspring, postnatal development, reproductive function of female, index of physical development, ind
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