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Vol. 19, Art. 10 (pp. 131-145)    |    2018       

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Assessment of effectiveness acisole and hyperbaric oxigenation for prevention of functional distrubances in the central nervous system caused by carbon monoxide poisoning in rats

Tolkach P.G., Basharin V.A., Solovyeva T.S., Chudakov V.S.

Military Medical Academy. S.M. Kirov

Brief summary

The laboratory animals were exposed to carbon monoxide (4200 ppm, 30 min). This led to the formation of a severe degree of intoxication, which was accompanied by a violation of the central nervous system. With a single administration of acyzole (60 mg / kg) and a session of hyperbaric oxygenation (1,5 atm, 10 min), there was no normalization of the reproduction of the food-procuring conditioned response and the elaboration swim-escape conditioned active avoidance response, both in the early and the late period of intoxication. Antidotes did not lead to normalization of the histoarchitectonics of the CA3 hippocampal field of rats by 21 days after exposure to carbon monoxide. Probably, for correction of disorders it is necessary to combine etiotropic therapy with drugs possessing neuroprotective mechanisms of action


Key words

carbon monoxide, intoxication, central nervous system, acisole, hyperbaric oxygenation, neuroprotection.

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