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Vol. 19, Art. 9 (pp. 117-130)    |    2018       

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Determination of antithrombotic activity of methylthiazole-and triazole-containing PPAR delta / beta agonists

Minin D.V., Popkov S.V., Burdeinyi M.L., Mantrov S.N., Goncharov V.M.,
Vasilevsky S.V.

D. Mendeleev University of Chemical Technology of Russia

Brief summary

The antithrombotic activity of five synthesized PPAR delta / beta agonists (2-methyl-4-[4-methyl-2-(4-trifluoromethylphenyl)-1,3-thiazole-5-ilmethylthio]-phenoxy)acetic acid was investigated as well as its two metabolites and two triazole analogues by measuring platelet aggregation in platelet-rich plasma. It was established that the sulfonic derivative of methylthiazole-containing acid has the highest antithrombotic activity.


Key words

PPAR agonists, antithrombotic activity, (2-methyl-4-[4-methyl-2-(4-trifluoromethylphenyl)-1,3-thiazole-5-ilmethylthio]-phenoxy)acetic acid, peroxisome proliferator-activated receptors, PPAR delta / beta

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