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Vol. 14, Art. 32 (pp. 362-389)    |    2013       

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Genetic factors to lung cancer predisposition

Brenishter S.I.

Moldavian Oncology Institute

Brief summary

The obvious combination of hereditary factors (genetic polymorphism) and surrounding environment factors (tobacco smoke) makes the lung cancer an interesting model for individual oncology predisposition investigation. It was investigated the role of unfavorable alleles of polymorphic genes, products of which assist the metabolism of tobacco smoke carcinogens in lung cancer risk appearance. It was shown, that the mutated allele with substitution of Т6235С into the gene CYP1A1, coding AGG enzyme, which activate PAH, is associated with lung cancer predisposition, especially to squamous cell carcinoma lung cancer. There are presented the data about small prevalence of deletion into the GSTM1 gene, coding in faze II of xenobiotic metabolism by lung cancer patients, which indicate the connection to risk appearance of this disease. It was communicated, that the unfavourable value of mutated allele in the CYP1A1 gene is increased in combination with deficiency of GSTM1 genotype. Into the work is shown that the polymorphic apoptotic gene Casp5, Casp8 and Dr4 should be considered into the large-scale case-control studies of lung cancer risk modifiers.


Key words

Lung cancer, genetic factors, predisposition, carcinogens, population, genes, polymorphism, DNA, allele

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