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"Институт токсикологии Федерального медико-биологического агентства"
(ФГБУН ИТ ФМБА России)

Институт теоретической и экспериментальной биофизики Российской академии наук.

ООО "ИЦ КОМКОН".




Адрес редакции и реквизиты

199406, Санкт-Петербург, ул.Гаванская, д. 49, корп.2

ISSN 1999-6314

Российская поисковая система
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«
Vol. 14, Art. 29 (pp. 313-335)    |    2013       
»

Role of cytokines in multiple myeloma pathogenesis
Pavlova A.A., Pavlova I.E., Bessmeltsev S.S.

Russian Institute of Hematology and Transfusion



Brief summary

The review shows structure, classification and cytokine biological activities. We describe that cytokines act as mediators forming complex interactions between the immune system and growing tumor. We summarize high polymorphism of cytokines and their receptors as well as characteristics of their gene expression. In this article we examine the role of major cytokines (e.g. IL-1β, IL-3, IL-6, IL-10, IL-11 and TNF-α) in the development of multiple myeloma – type of cancer formed by malignant blood cells - and observe cytokines involved in processes of bone destruction which are common for patients with this type of cancer.


Key words

cytokines, genetic polymorphism, multiple myeloma, single nucleotide polymorphisms





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Reference list

1. Cohen S., Bigazzi P.E., Yoshida T. Similarities of T cell function in cell-mediated immunity and antibody production// Cell Immunology. - 1974. – Vol. 12. - P. 150


2. Kadagidze Z.G. Citokini// Prakticheskaya onkologiya. – 2003. - T. 4, № 3. - S. 131-139.


3. Wong E., Freiberg M. et al. Epidemiology of cytokines// American Journal of Epidemiology. – 2008. - Vol. 168, N 4. – P. 443-453.


4. Belova O.V., Arion V.Ya., Sergienko V.I. Rol citokinov v immynologicheskoi fynkcii koji// Immynopatologiya, allergologiya, infektologiya. – 2008. - № 1. - S. 41-55.


5. Jarov I.A., Demihov V.G., Novikov A.V., i dr. Rekombinantnii interleikin-1β (betaleikin) v kompleksnoi terapii neonatalnogo sepsisa// Citokini i vospalenie. – 2008. - T.7. - C. 63-66.


6. Ketlinskii S.A., Simbircev A.S. Citokini// izd. «Foliant». – 2008. – 552 C.


7. Landishev U.S., Syrov A.V., Lazytkina E.L. i dr. Rol citokinov i polimorfno-yadernih neitrofilov v patogeneze bronhialnoi astmi// Dalnevostochnii medicinskii jyrnal. – 2008. - №2. - C. 134-138.


8. Chechina O.E., Biktasova A.K., Sazonova E.V. i dr. Rol citokinov v redoks-zavisimoi regylyacii apoptoza// Bulleten sibirskoi medicini. – 2009. - №2.- C. 67-72.


9. Neuhoff S., Moers J., et al. Proliferation, differentiation and cytokine secretion of human umbilical cord blood-derived mononuclear cells in vitro// Experimental Hematology. - 2007. - Vol. 35. - P. 1119-1131.


10. Lisenko O.V., Zanko S.N. Citokini i sFAS-ligand pri giperplasticheskih processah i polipah endometriya// Problemi reprodyktologii. – 2010. - T.5. - C. 31-35.


11. Simbircev A.S. Citokini: klassifikaciya i biologicheskie fynkcii// Citokini i vospalenie. -2004. - № 2. - S. 16-22.


12. Mordvinov V.A., Fyrman D.P. Citokini: biologicheskie svoistva i regylyaciya ekspressii gena interleikina-5 cheloveka// Vestnik VOGiS. – 2009. - T.13. - C. 53-67.


13. Serebrennikova S.N., Seminskii I.J. Vliyanie citokinov na kletki ochaga vospaleniya// Problemi i perspektivi sovremennoi nayki. – 2009. - T.2. - № 1.- C. 5-9.


14. Simbircev A.S. Citokini – novaya sistema regylyacii zashitnih reakcii organizma// Citokini i vospalenie.- 2002. - №1. - C. 9-16.


15. Gonzalez S., Naranjo A., Serrano L.M., et al. Genetic engineering of cytolytic T lymphocytes for adoptive T-cell therapy of neuroblastoma// The journal of gene medicine. – 2004. - Vol. 6. - P. 704-711.


16. Steinman L., Engineering better cytokines// Nature Biotechnology. – 2003. - Vol. 23. - P. 1293-1294.


17. Vilcek J. The cytokines: An overwiev// The Cytokine Handbook. - 3rd Edition. - Academic Press. – 2008. – P. 3-18.


18. Ikram N., Hassan K., Tufail S. Cytokines// International Journal of Pathology. – 2004. -Vol.2. - P. 47-58.


19. Liongue C., Ward A.C. Evolution of class I cytokine receptors// BMC Evolutionary Biology. – 2007. - Vol. 7. - P.1-15.


20. Economides A.N., Carpenter L.R., Rudge J.S., et al. Cytokine traps: multi-component, high-affinity blockers of cytokine action// Nature Medicine. – 2003. - Vol. 9. - N 1. - P. 47-52.


21. Kozlov V.A. Nekotorie aspekti problemi citokinov// Citokini i vospalenie. – 2002. - №1. - C.1-8.


22. Baker S.J., Rane S.G., Reddy E.P. Hematopoietic cytokine receptor signaling// Oncogene. - 2007. - Vol. 15. - P. 6724-6737.


23. Vasserman E.N., Lyamina S.V., Shimshelashvili Sh.L. i dr. SP-D kontroliryet balans TN1 i TN2 citokinov i obladaet priznakami endogennogo faktora reprogrammirovaniya makrofagov// Fyndamentalnie issledovaniya. – 2010. - № 6. - C. 28-36.


24. Wrzenski S.H., Wan Y.Y., Flavell R.A. Transforming growth factor-β and the immune response: implications for anticancer therapy// Clinical Cancer Research. – 2007. - Vol. 13. - P. 5262-5270.


25. Coico R., Sunshine G. Immunology: A Short Course// Wiley-Blackwell. - 6 Edition. -2009. – 416 P.


26. Locksley R.M., Killeen N., Leonardo M.J. The TNF and TNF receptor superfamilies: integrating mammalian biology// Cell. – 2001. - Vol. 104. - P. 487-501.


27. Barclay A. Membrane proteins with immunoglobulin-like domains- a master superfamily of interaction molecules// Semin Immunology. – 2003. - Vol. 15. – P. 215-223.


28. Murdoch C., Finn A. Chemokine receptors and their role in inflammation and infectious diseases// Blood. – 2000. - Vol. 95. - P. 3032-3043.


29. Hebenstreit D., Horejs-Hoeck J., et al. JAK/STAT-dependent gene regulations by cytokines// Drug News Perspect. – 2005. - Vol. 18. - P.243-249.


30. Shuai K., Liu B. Regulation of Jak-STAT signalling in the immune system// Nature Reviews Immunology. – 2003. - Vol. 3. - P. 900-911.


31. Mollaeva N.O., Nasryllaeva G.M., Gyliev N.D. Izychenie citokinovogo statysa y novorojdennih i detei grydnogo vozrasta s vnytriytrobnimi infekciyami// Medicinskie Novosti. – 2011. - №2. - C. 98-100.


32. Caplan A.I., Dennis J.E. Mesenchymal stem cells as trophic mediators// Journal of Cellular Biology. – 2006. - Vol. 98. - P. 1076-1084.


33. Grunstein M.M., Hakonarson H., Maskeri N. et al. Autocrine cytokine signaling mediates effects of rhinovirus on airway responsiveness// American Journal of Physiology – Lung Cellular and Molecular Physiology. – 2000. - Vol. 278. - P. L1146-L1153.


34. Gnecchi M., Zhang Z., et al. Paracrine mechanisms in adult stem cell signaling and therapy// Circulation Research. – 2008. - Vol. 103. - P. 1204-1219.


35. Imlach W., McCaughan C.A., Mercer A.A., et al. Orf virus-encoded interleukin-10 stimulates the proliferation of murine mast cells and inhibits cytokine synthesis in murine peritoneal macrophages// Journal of General Virology. – 2002.- Vol. 83. - P. 1049-1058.


36. Iqaz P., Falus A., et al. Cytokines in diseases of the endocrine system// Cell biology International. – 2000. - Vol. 24. - P. 663-668.


37. Stumpo D.J., Lai W.S., Blackshear P.J. Inflamation: cytokines and RNA-based regulation// Wiley Interdisciplinary Reviews RNA. - 2010. - Vol. 1. - P. 60-80.


38. Lacy P., Stow J.L. Cytokine release from innate immune cells: association with diverse membrane trafficking pathways// Blood. – 2011. - Vol. 118. - P. 9-18.


39. Steele L., Errington F., Prestwich R., et al. Pro-inflammatory cytokine/chemokine production by reovirus treated melanoma cells is PKR/NF-κB mediated and supports innate and adaptive anti-tumor immune priming// Molecular cancer. – 2011. - vol. 10. - P. 1-13.


40. Wright R.J., Visness C.M., Calatroni A., et al. Prenatal maternal stress and cord blood innate and adaptive cytokine responses in an inner-city cohort// American Journal of Respiratory and Critical Care Medicine. – 2010. - Vol. 182. - P. 25-33.


41. Kyrchenko A.I., Drannik G.N. Immynofenotipicheskaya kartina i citokinovii profil perifericheskoi krovi bolnih v ostroi i hronicheskoi stadii razvitiya atopicheskogo dermatita// Dermatologiya. – 2006. - №2. - C. 9-12.


42. Ouyang S., He F. Phylogeny of a growth hormone-like cytokine superfamily based upon 3D structure// Journal of Molecular Evolution. - 2003.- Vol. 56. - P. 131-136.


43. Marshak-Rothstein A. Toll-like receptors in systemic autoimmune disease// Nature Reviews. Immunology. – 2006. - Vol. 6. - P. 823-835.


44. Fox B.A., Sheppard P.O., O’Hara P.J. The role of genomic data in the discovery, annotation and evolutionary interpretation of the Interferon-Lambda family// PLoS One. – 2009. - Vol. 4. - P.1-7.


45. Teletaeva G.M. Citokini i protivoopyholevii immynitet// Prakticheskaya onkologiya. – 2007. - T. 8. - C. 211-218.


46. Rose-John S., Schooltink H. Cytokines are therapeutic target for the prevention of inflammation-induced cancers// Recent Results of Cancer Research. – 2007. - Vol. 174. - P. 57-66.


47. Fischereder M. Chemokines and chemokine receptors in renal transplantation – from bench to bedside//  Acta Physiologica Hungarica. – 2007. - Vol. 94. - P. 67–81.


48. Allen S.J., Crown S.E., Handel T.M. Chemokine: receptor structure, interactions, and antagonism// Annual Review of Immunology. – 2007. - Vol. 25. - P. 787–820.


49. Alves N.L., Arosa F.A., van Lier R.A. Common gamma chain cytokines: dissidence in the details// Immunology Letters. – 2007. - Vol. 108. - P. 113–120.


50. Bunting K., Wang J., Shannon M.F. Control of interleukin-2 gene transcription: a paradigm for inducible, tissue-specific gene expression// Vitamins and Hormones. – 2006. - Vol. 74. - P. 105–145.


51. Li B., Carey M., Workman J.L. The role of chromatin during transcription// Cell. – 2007. - Vol. 128. - P. 707–719.


52. Narlikar G.J., Fan H.Y., Kingston R.E. Cooperation between complexes that regulate chromatin structure and transcription// Cell. - 2002. - Vol. 108. - P. 475–487.


53. Santana M.A., Rosenstein Y. What it takes to become an effector T cell: the process, the cells involved and the mechanisms// Journal of Cellular Physiology. – 2003. - Vol. 195. - P. 392–401.


54. Yarilin A.A., Belyakov I.M. Cytokines in the thymus: production and biological effects// Current Medicinal Chemistry. - 2004. - Vol. 11. - P. 447–464.


55. Holloway A.F., Rao S., Shannon M.F. Regulation of cytokine gene transcription in the immune system// Molecular Immunology. – 2002.- Vol. 38.- P. 567–580.


56. Adamopoulos S., Kolokathis F., Gkouziouta A., et al. Cytokine gene polymorphisms are associated with markers of disease severity and prognosis in patients with idiopathic dilated cardiomyopathy// Cytokine.- 2011.- Vol. 54.-N 1.- P. 68-73.


57. Nemeth J., Winkler H.M., Zwick R.H., et al. Peripherial T cell cytokine responses for diagnosis of active tuberculosis// PLoS ONE.- 2012.- Vol.7.- P. :e35290.


58. Sabatos-Peyton C.A., Verhagen J., Wraith D.C. Antigen-specific immunotherapy of autoimmune and allergic diseases// Current Opinion in Immunology.- 2010.- Vol. 22.- P. 609-615.


59. Terryberry J., Armstrong G., Sawyer J. SQI diagnostics human cytokine 8-plex microarray// SQI Diagnostics. - 2012.- P. 1-4.


60. Demyanov A.V.. Kotov A.U., Simbircev A.S. Diagnosticheskaya cennost issledovaniya yrovnei citokinov v klinicheskoi praktike// Citokini i vospalenie. – 2003. - №3.- C. 20-35.


61. Konenkov V.I., Rakova I.G., Maksimov V.N., i dr. Allelnii polimorfizm genov pro- i protivovospalitelnih citokinov pri infarkte miokarda v evropeoidnoi popylyacii myjchin// Bulleten SO RAMN. – 2006. - N 2. - C. 56-62.


62. Konenkov V.I. Citokinovie poligennie kompleksi - markeri individyalnoi nastroiki sostoyaniya citokinovoi seti zdorovogo cheloveka i pacientov s zabolevaniyami razlichnoi prirodi// Allergologiya i immynologiya. – 2011. - N 2. - C. 191-194.


63. Dunn G.P., Koebel C.M., Schreiber R.D. Interferons, immunity and cancer immunoediting// Nature Reviews Immunology. – 2006. - Vol. 6. - P. 836–848.


64. Bessmelcev S.S., Abdylkadirov K.M. Mnojestvennaya mieloma// izd. «Dialekt».- 2004. - 448 s.


65. Kuehl W.M., Bergsagel P.L. Molecular pathogenesis of multiple myeloma and its premalignant precursor// The Journal of Clinical Investigation. – 2012. - Vol. 122. – N 10. - P. 3456–3463.


66. Chernish N.U., Bessmelcev S.S., Kozlov A.V. i dr. Apoptoticheskaya aktivnost kletok kostnogo mozga bolnih mnojestvennoi mielomoi// Vestnik Gematologii. – 2009. - T.5. - C. 5-11.


67. Bessmelcev S.S., Abdylkadirov K.M. Yspehi, neydachi i perspektivi v lechenii mnojestvennoi mielomi// Voprosi onkologii. – 2002. -N 2. - C. 146-152.


68. Andreeva N.E., Balakireva T.V. Paraproteinemicheskie gemoblastozi (immynoglobylin-sekretiryushie limfomi), Rykovodstvo po gematologii// Nudiamed. – 2003. - N 2. - C. 151-184.


69. Alexander D.D., Mink P.J., Adami H., et al. Multiple myeloma: a review of the epidemiologic literature// International Journal of Cancer. – 2007. - Vol. 120. - P. 40-61.


70. Yiin J.H., Anderson J.L., Daniels R.D., et al. A Nested case-control study of multiple myeloma risk and uranium exposure among workers at the oak ridge gaseous diffusion plant// Radiation Research. – 2009. - P. 637-645.


71. Lynch H.T., Sanger W.G., Pirruccello S., et al. Familial multiple myeloma: a family study and review of the literature// Journal of the National Cancer Institute. – 2001. - Vol. 93. - P. 1479-1483.


72. Pearse R.N., Sordillo E.M., Yaccoby S., et al. Mulyiple myelomas disrupts the TRANCE/osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression// PNAS. – 2001. - Vol. 98. - P. 11581-11586.


73. Johrer K., Janke K., Krugmann J., et al. Transendothelial Migration of Myeloma Cells Is Increased by Tumor Necrosis Factor (TNF)-α via TNF Receptor 2 and Autocrine Up-Regulation of MCP-1// Clinical Cancer Research. – 2004. - Vol. 10. - P. 1901-1910.


74. Zheng M.M., Zhang Z., Bemis K., et al. The Systemic Cytokine Environment Is Permanently Altered in Multiple Myeloma// PLoS ONE. – 2013. - Vol. 8. - N 3. - P. 1-10.


75. Abdylkadirov K.M. Klinicheskaya gematologiya: Spravochnik// izd. «Piter». – 2006. - 448 s.


76. Salazar-Onfray F., Lopez M.N., Mendoza-Naranjo A. Paradoxical effects of cytokines in tumor immune surveillance and tumor immune escape// Cytokine Growth Factor Reviews. – 2007. - Vol. 18. – NN 1-2. - P. 171-182.


77. Caligiuri M.A., Lotze M.T. Cytokines in multiple myeloma// Cytokines in the Genesis and Treatment of Cancer. – 2007. - P. 181-197.


78. Chauhan D., Hideshima T., Anderson K. Cytokines in multiple myeloma. Therapeutic implications// Cancer Drug Discovery and Development. – 2007. - Vol. 2. - P. 181-197.


79. Loffer D., Brocke-Heidrich K., Pfeifer G., et al. IL-6-dependent survival of multiple myeloma cells involves the Stat-3-mediated induction of microRNA-21 through a highly conserved enhancer// Blood. – 2007. - Vol. 110. - P. 1330-1333.


80. Ishikawa H., Tsuyama N., Obata M., et al. Mitogenic signals initiated via interleukin-6 receptor complexes in cooperation with other transmembrane molecules in myelomas// Journal of Clinical and Experimental Hematopathology. – 2006. - Vol. 46. – N 2. - P. 55-66.


81. Petrucci M.T., Ricciardi M.R., Gregorj C., et al. Effects of IL-6 variants in multiple myeloma: growth inhibition and induction of apoptosis in primary cells// Leukemia and Lymphoma. -2002. - Vol. 43. - N 12. - P. 2369-2375.


82. Svistynov A.A., Ryta A.V., Shevchenko O.V. Osobennosti kostnogo metabolizma y bolnih mnojestvennoi mielomoi// Saratovskii naychno-medicinskii jyrnal. -2010. - T. 6. – N 1. - C. 48-52.


83. Roodman G.D. Biology of osteoclast activation in cancer// Journal of Clinical Oncology. – 2001. - Vol. 19. - P. 3562-3571.


84. Gelcer B.I., Jilkova N.N., Anyfrieva N.D., i dr. Porajenie kostei pri mnojestvennoi mielome// Tihookeanskii medicinskii jyrnal. – 2011. - N 3. – C. 11-16.


85. Dinarello C. IL-1 in the pathogenesis and treatment of inflammatory diseases// Blood. – 2011. - Vol. 117. - P. 3720-3732.


86. Donovan K.A., Lacy M.Q., Gertz M.A., et al. IL-1b expression in IgM monoclonal gammopathy and its relationship to multiple myeloma// Leukemia. – 2002. - Vol. 16. - P. 382-385.


87. Terpos E. and Dimopoulos M.-A. Myeloma bone disease: pathophysiology and management// Annals of oncology. – 2005. - Vol. 16. - P. 1223-1231.


88. Chevrel G., Granet C., Miossec P. Contribution of tumour necrosis factor α and interleukin (IL) 1β to IL6 production, NF-kB nuclear translocation, and class I MHC expression in muscle cells: in vitro regulation with specific cytokine inhibitors// Annual Rheum Dis. – 2005. - Vol. 64. - P. 1257-1262.


89. Kovacs E. IL-6 leads to IL-10 production in several human multiple myeloma cell lines. Does IL-10 enhance the proliferation of these cells?// Leukemia Research. – 2010. - Vol. 34. - P. 912-916.


90. Roodman G.D. Mechanisms of bone metastasis// The New England Journal of Medicine. – 2004. - Vol. 350. - P. 1655-1664.


91. Cheung W.C., Van Ness B. Distinct IL-6 signal transduction leads to growth arrest and death in B cells or growth promotion and cell survival in myeloma cells// Leukemia. – 2002. - Vol. 16. - P. 1182-1188.


92. Choi S.J., Cruz J.C., Craig F., et al. Macrophage inflammatory protein 1-alpha is a potential osteoclast stimulatory factor in multiple myeloma// Blood. – 2000. - Vol. 96. - P. 671-675.


93. Han J.H., Choi S.J., Kurihara N., Koide M., et. al. Macrophage inflammatory protein-1alpha is an osteoclastogenic factor in myeloma that is independent of receptor activator of nuclear factor kappaB ligand// Blood. – 2001. - Vol. 97. - P. 3349-3353.


94. Uneda S., Hata H., Matsuno F., et al. Macrophage inflammatory protein-1 alpha is produced by human multiple myeloma (MM) cells and its expression correlates with bone lesions in patients with MM// British Journal of Haematology. – 2003. - Vol. 120. - P. 53-55.


95. Choi S.J., Oba Y., Gazitt Y., et al. Antisense inhibition of macrophage inflammatory protein 1-alpha blocks bone destruction in a model of myeloma bone disease// Journal of Clinical Investigation. – 2001. - Vol. 108. - P. 1833-1841.


96. Magrangeas F., Nasser V., Avet-Loiseau H., et al. Gene expression profiling of multiple myeloma reveals molecular portraits in relation to the pathogenesis of the disease// Blood. – 2003. - Vol. 101. - P. 4998-5006.


97. Oyajobi B.O., Franchin G., Williams P.J., et al. Dual effects of macrophage inflammatory protein-1alpha on osteolysis and tumor burden in the murine 5TGM1 model of myeloma bone disease// Blood. – 2003. - Vol. 102. - P. 311-319.


98. Manzuk L.V. Anti-RANKL monoklonalnoe antitelo i ego ispolzovanie v onkologii// Prakticheskaya Onkologiya. – 2011. - T.12. - C. 132-135.


99. Sezer O., Heider U., Jakob C., Eucker J., Possinger K. Human bone marrow myeloma cells express RANKL// Journal of Clinical Oncology. – 2002. - Vol. 20. - P. 353-354.


100. Terpos E., Dimopoulos M.-A., Sezer O. The effect of novel anti-myeloma agents on bone metabolism of patients with multiple myeloma// Leukemia. – 2007. - Vol. 21. - P. 1875-1884.


101. Dougall W.C., Chaisson M. The RANK, RANKL, OPG triad in cancer-induced bone diseases// Cancer and Metastasis Reviews. – 2006. - Vol. 25. - P. 541-549.


102. Sezer O., Heider U., Jakob C., et al. Immunocytochemistry reveals RANKL expression of myeloma cells// Blood. – 2002. - Vol. 99. - P. 4646-4647.


103. Tian E., Zhan F., Walker R., et al. The role of the Wnt/b-catenin signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma// The New England Journal of Medicine. – 2003. - Vol. 349. - P. 2483-2494.



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