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Федеральное государственное бюджетное учреждение науки
"Институт токсикологии Федерального медико-биологического агентства"

Институт теоретической и экспериментальной биофизики Российской академии наук.


Адрес редакции и реквизиты

199406, Санкт-Петербург, ул.Гаванская, д. 49, корп.2

ISSN 1999-6314

Российская поисковая система

Vol. 9, Art. 21 (pp. 240-254)    |    2008       

Brief summary

Radiation therapy and chemotherapy (RCT) by genotoxic cytostatic drugs are widely used in oncology. In this study we demonstrate that RCT induces alteration in mtDNA copy number in peripheral blood of cancer patients. Moreover, AFLP analysis of short tandem repeat loci has shown that after RCT course, deletions and insertions appeared in STR loci. These deletions and insertions, in most cases appear in patients with significant dynamic of mtDNA copy number changing.

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