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«
ТОМ 9, СТ. 20 (стр. 196-240)   |   ноябрь 2008 г.   
»

Фундаментальные исследования » Биофизика

Дифференцировка клеток обратима: соматические научились превращать в плюрипотентные стволовые
Бочарова Л.С.

Институт теоретической и экспериментальной биофизики РАН
Пущино, Московская область



Резюме

Серьезный прорыв в области клеточных технологий сделал возможным превращение различных соматических клеток в индуцированные плюрипотентные стволовые (iPS) клетки. По свойствам они аналогичны клеткам внутренней клеточной массы бластоцисты (ICM) и эмбриональным стволовым (ES) клеткам. iPS клетки активно пролиферируют in vitro, сохраняя свойства недифференцированных клеток, и в то же время способны превращаться в любые клетки организма. В обзоре анализируются свойства iPS клеток мышей и человека, методы их получения, молекулярные механизмы трансформации специализированных клеток, возможность их применении в медицинской практике.


Ключевые слова

дифференцировка, плюрипотентность, индукторы, эпигенетические изменения, клеточная терапия, источники клеток





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