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Vol. 24, Art. 1 (pp. 1-16)    |    2023       

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Molecular genetic features of the vesiculomembrane snare-complex associated with the risk of development of neurodegenerative diseases

Antonova1 E.N., Babkin1 A.V., Kravtsov1 I.S., Makhlai1 A.A., Ivanov1 I.M., Yudin1,2 M.A.

Feredal State Budgetary Establishment «State Scientific Research Test Institute of the military medicine» Defense Ministry of the Russian Federation
Federal State-Funded Education Institution of Higer Professional Education North-Western state Medical University named after I. I. Mechnikov (NWSMU), Ministry of Health of the Russian Federation

Brief summary

The review considers the structure, functioning and molecular genetic features of the main proteins of the vesicle-membrane SNARE complex (syntaxin-1, SNAP-25, Munc13-1, Munc18-1, synaptobrevin-2). Structural features (polymorphism) and the level of expression of genes encoding SNARE proteins were analyzed for association with phenotypic features and the risk of developing diseases of the central and peripheral nervous system in humans and animals. The relevance of research directions to find the relationship between individual molecular genetic features of the SNARE complex and the development of neurodegenerative diseases is emphasized. The expediency of taking into account the variants and the level of expression of the genes encoding proteins of the SNARE complex for predicting the development and developing a personalized approach to the treatment of neurodegenerative diseases was noted.


Key words

SNARE proteins, syntaxin-1, SNAP-25, Munc13-1, Munc18-1, synaptobrevin-2, neurodegenerative diseases, gene, polymorphism, personalized approach.

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