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Vol. 23, Art. 28 (pp. 481-498)    |    2022       

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Biotechnologies in the treatment of burn lesions (Review of literature)

Derii E.K.1, Kostyakov D.V.1, Movchan K.N.2, Pyatakov S.N.2, Manukovskiy V.A.1

1. State Healthcare Institution «Saint-Petersburg Research Institute of Emergency Medicine named after I. I. Dzhanelidze»
2. State Healthcare Institution «Medical analytical center»
3. State Healthcare Institution «City Hospital ?4»

Brief summary

Burn injury is a serious global problem. Despite the many ways to treat this pathology, the search for more modern and effective methods remains relevant. One of these areas is biotechnology. Modern biotechnological cell products used in clinical medicine include the use of cultured keratinocytes, fibroblasts, stem cells and various living skin equivalents. Other promising technologies are also described in the literature, many of which are experimental. These include: 3D bioprinting, reprogramming of somatic cells, the use of three-dimensional grid matrices. Methods of biotechnological restoration of the skin cover have a number of disadvantages. The main ones include: the high cost of developing and using cell products, the need for expensive equipment and highly qualified specialists in a medical institution, and unresolved issues in the legal field. Nevertheless, overcoming these problematic aspects will make it possible to routinely apply biotechnologies in the treatment of burn patients with high efficiency.


Key words

skin burns, skin restoration, biomedical cell product, stem cells, fibroblasts, keratinocytes.

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