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 УЧРЕДИТЕЛИ:
Федеральное государственное бюджетное учреждение науки
"Институт токсикологии Федерального медико-биологического агентства"
(ФГБУН ИТ ФМБА России)

Институт теоретической и экспериментальной биофизики Российской академии наук.

ООО "ИЦ КОМКОН".




Адрес редакции и реквизиты

199406, Санкт-Петербург, ул.Гаванская, д. 49, корп.2

ISSN 1999-6314

Российская поисковая система
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«
Vol. 21, Art. 64 (pp. 799-809)    |    2020       
»

Action of the chemical toxicants on regulation of the oxidative processes
Emanuel Institute of Biochemical Physics of Russian Academy if Sciences



Brief summary

Cuprum ions characterizing a high toxicity is experimentally established to accelerate the spontaneous low-temperature oxidation of lecithin (a mixture of the natural lipids) according to the phospholipid share in their total lipid composition. Both the intraperitoneal administration of Tween 80 which is used as a solubilizer in medicine in the 10% aqueous solution of acetone (a low toxicity solvent) and the presence in drinking water of the black liquor (industrial toxicant) at the wide range of concentrations result to the essentially disruptions of the oxidation processes regulation in the liver of mice. It is supposed that existence of the changed cell metabolism for a long time is due to the toxicity of studied actions.


Key words

Lipids, peroxidation, regulation, cuprum ions, Tween 80, acetone, black liquor.





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Reference list

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Reference


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2. Shishkina L.N., Klimovich M.A., Kozlov M.V. Functioning Similarity of the Physicochemical Regulatory System of the Lipid Peroxidation on the Membrane and Organ Levels / Pharmaceutical and Medical Biotechnology: New Perspectives. N.Y.: Nova Science Publishers, Inc., 2013. Chapter 14. P. 151-157.


3. Valko M., Leibfritz D., Moncol J., Cronin M.T.D., Mazur M., Tesler J. Free Radicals and antioxidants in normal and physiological functions and human disease / IJBCB. 2007. Vol. 39. P. 44-84. doi: 10.1016/j.biocel.2006.07.001


4. Keshari A.K., Verma A.K., Kumar T., Srivastava R. Oxidative Stress. A review / The International Journal of Science & Technology. 2015. Vol. 3. N. 7. P. 155-162.


5. Shishkina L.N., Klimovich M.A., Kozlov M.V A New Approach to Analysis of Participation of Oxidative Processes in Regulation of Metabolism in Animal Tissues / Biophysics. 2014. Vol. 59. N. 2. P. 310-315.


6. Jones C.M., Burkitt M.J. EPR spin-trapping evidence for the direct, one-electron reduction of tert-butylhydroperoxide to the tert-butoxyl radical by copper(II): paradigm a previously overlooked reaction in the initiation of lipid peroxidation / J. Am. Chem. Soc. 2003. Vol. 125. N. 23. P. 6946-6954.


7. Lyalina E.I. Fokina A.I., Ashikhmina T.Ya., Olkova A.S., Beresneva E.V., Darovskikh L.V., Yarmolenko A.S. Comprehensive chemical-toxicological research of copper(II) sulfate solutions containing reduced glutation / Teoreticheskaya i prikladnaya ekologiya. 2018. ? 2. S. 101-107 [In English].


8. Marakulina K.M., Kramor R.V., Lukanina Yu.K., Plashchina I.G., Polyakov A.V., Fedorova I.V., Chukicheva I.Yu., Kutchin A.V., Shishkina L.N. Effect of the phospholipid nature on scale of their interaction with antioxidants of a new class - isobornylphenols / Journal of the Physical Chemistry. 2016. Vol. 90. N 2. P. 182- 189 [In Russian].


9. Dib B., Falchi M. Convulsions and death induced in rats by Tween 80 are prevented by capsaicin / Int. J. Tissue React. 1996/ Vol. 18. N 1. P. 27-31.


10. Shishkina L.N., Kushnireva Ye.V., Smotryaeva M.A. The combined effect of surfactant and acute irradiation at low dose on lipid peroxidation process in tissues and DNA content in blood plasma of mice / Oxidation Communication. 2001. Vol. 24. N 2. P. 276-286.


11. Varma R.K., Kaushal R., Junnarkar A.Y. et al. Polysorbate 80: A pharmacological study / Arzneimittelforschung 1985. Bd. 35. N 3. S. 804-808.


12. Kozlov M.V., Kushnireva Ye.V., Urnysheva V.V., Taran Yu.P., Shoshkina L.N. Effect of characteristics of lipids on regulation of the biochemical processes in liver and blood of mice / Biofizika = Biophysics. 2007. Vol. 52. N 4. P. 693-698 [In Russian].


13. Kates M. The Technique of lipidology. M.: Mir, 1975. 322 p. (Russian version).


14. Shishkina L.N., Kushnireva Ye.V., Smotryaeva M.A. A new approach to assessment of biological consequences of exposure to low-dose radiation // Radiaz. Biologiya. Radioekologiya = Radiation biology. Radioecology. 2004. V. 44. ? 3. P. 289-295 [In Russian].


15. Asakawa T., Matsushita S. Coloring Conditions of Thiobarbituric Acid Test for Detecting Lipid Hydroperoxides / Lipids. 1980. Vol.15. N 3. P. 137-140.


16. Itzhaki R., Gill D.M. A micro-biuretic method for estimating proteins / Anal. Biochemistry. 1964. Vol. 9. P. 401-410.


17. Brin E.F., Travin S.O. Modeling the mechanisms of chemical reactions // Chemical Physics. 1991. V. 10. N 6. P. 830-837 [In Russian]





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