Медико-биологический
информационный портал
для специалистов
 
БИОМЕДИЦИНСКИЙ ЖУРНАЛ Medline.ru

СОДЕРЖАНИЕ ЖУРНАЛА:
Физико-химическая биология

Клиническая медицина

Профилактическая медицина

Медико-биологические науки


АРХИВ:

Фундаментальные исследования

Организация здравохраниения

История медицины и биологии



Последние публикации

Поиск публикаций

Articles

Архив :  2000 г.  2001 г.  2002 г. 
               2003 г.  2004 г.  2005 г. 
               2006 г.  2007 г.  2008 г. 
               2009 г.  2010 г.  2011 г. 
               2012 г.  2013 г.  2014 г. 
               2015 г.  2016 г.  2017 г. 
               2018 г.  2019 г.  2020 г. 

Редакционная информация:
        Опубликовать статью
        Наша статистика


 РЕДАКЦИЯ:
Главный редактор

Заместители главного редактора

Члены редколлегии
Специализированные редколлегии


 УЧРЕДИТЕЛИ:
Федеральное государственное бюджетное учреждение науки
"Институт токсикологии Федерального медико-биологического агентства"
(ФГБУН ИТ ФМБА России)

Институт теоретической и экспериментальной биофизики Российской академии наук.

ООО "ИЦ КОМКОН".




Адрес редакции и реквизиты

199406, Санкт-Петербург, ул.Гаванская, д. 49, корп.2

ISSN 1999-6314

Российская поисковая система
Искать: 


«
Vol. 21, Art. 39 (pp. 489-505)    |    2020       
»

Non-tumor pathology in children of female workers of multi- industry mayak production association
Southern Urals Biophysics Institute, Russian Federation,
456780, Ozyorsk, 19 Ozerskoye shosse, Laboratory of Radiation Epidemiology



Brief summary

Retrospective epidemiological study was performed based on a cohort of personnel of Mayak Production Association (Mayak PA) employed in 1948-1982 and on the Ozyorsks children Health Registry. Incidence of non-tumor pathology was traced among 10581 children under 15; 1742 of them were offspring of 1266 Mayak PA female workers exposed to preconception radiation. Children of unexposed parents (n=8839) made the comparison group. Incidence rate of children?s morbidity by classes of non-tumor pathology was calculated. Statistical analysis was performed using nonparametric statistics. Comparing to a group of offspring of unexposed parents one may note statistically significant increase of incidence rate of chronic pathology of lower respiratory tract, allergodermathosis, diseases of upper gastrointestinal, pathologies of eye muscular system. Significant predominance over a group of unexposed parents was registered for endocrine diseases as a whole including non-tumor thyroid pathology with a significant contribution of a subgroup of girls, daughters of exposed mothers; for diseases of the musculoskeletal system and connective tissue including deforming dorsopathies; for diseases of the circulatory system due to non-rheumatic heart diseases. High incidence of polymorbidities was registered in a group of offspring of mothers exposed to radiation prior to conception. Dose categories of maternal preconception occupational exposure, in which there was a statistically significant excess of the level of non-tumor pathology in the offspring, are indicated. The detected differences do not exclude a specific role of preconception exposure of gonads in development of nonneoplastic pathology in offspring that requires further analysis.


Key words

non-tumor incidence, children, radiation, parental exposure, Mayak PA





(The article in PDF format. For preview need Adobe Acrobat Reader)



Open article in new window

Reference list

1. Volosnikov D.K., Sosnina S.F. Mediko-socialnaya harakteristika semei, projivaushih v zakritom administrativnom territorialnom obrazovanii (g. Ozersk), imeushih detei podrostkovogo vozrasta / Sociologiya medicini. 2010. N 2 (17). C. 59-61.


2. Kommentarii k Normam radiacionnoi bezopasnosti (NRB-99/2009) / pod red. akademika RAMN G.G. Onishenko. SPb.: NIIRG, 2012. 216 s.


3. Korenev N.M., Borisko G.A., Kashina - Yarmak V.L. Sostoyanie zdorovya detei, rojdennih v semyah roditelei, oblychennih vsledstvie avarii na Chernobilskoi AES / Zdorove rebenka. 2012. N 6. C. 66-70.


4. Koreckaya L.S., Samotiya E.E., Ecko L.A., Kornesky A.V., Koreckaya L.I. Ocenka otdalennih posledstvii avarii na ChAES. Sostoyanie zdorovya detei, rojdennih v semyah likvidatorov posle ychastiya v likvidacii posledstvii avarii / Zdorove i okryjaushaya sreda. 2009. N 14. C. 565-573.


5. Koshyrnikova N.A., Shilnikova N.S, Okatenko P.V., Kreslov V.V., Bolotnikova M.G., Sokolnikov M.E., Romanov S.A., Hohryakov V.F., Syslova K.G., Vasilenko E.K. Harakteristika kogorti rabotnikov atomnogo predpriyatiya PO «Mayak» (chast II) / Voprosi radiacionnoi bezopasnosti. 1998. N 3. C. 48-58.


6. Kychma V.R., Syharev A.G. Gigiena detei i podrostkov kak razdel profilakticheskoi medicini / Gigiena i sanitariya. 2015. N 94(6). C. 66-70.


7. Lyaginskaya A.M., Tykov A.R., Osipov V.A., Prohorova O.N. Geneticheskie effekti y likvidatorov posledstvii avarii na Chernobilskoi AES / Radiacionnaya biologiya. Radioekologiya. 2007. T. 47, N 2. S. 188-195.


8. Mejdynarodnaya statisticheskaya klassifikaciya boleznei i problem, svyazannih so zdorovem. Desyatii peresmotr, Tom 1 (chast 2). M.: Medicina, 1995. 633 s.


9. Merkov A.M., Polyakov L.E. Sanitarnaya statistika (posobie dlya vrachei). L.: «Medicina», Leningradskoe otdelenie, 1974. 384 c.


10. Moleva V.I., Kashina-Yarmak V.L. Osobennosti sostoyaniya zdorovya i immynologicheskogo gomeostaza y detei, roditeli kotorih projivali v zonah radiacionnogo zagryazneniya v detskom i podrostkovom vozraste / Mediko-biologicheskie problemi jiznedeyatelnosti. 2011. N 1(5). C. 42-47.


11. Naida V.G. Obyazatelnaya specialnaya dispanserizaciya i dinamicheskoe nabludenie v medicinskom obslyjivanii «detei chernobilcev»: nedostatki i pyti ih ispravleniya / Vestnik Sankt-Peterbyrgskogo yniversiteta. Seriya 11. Medicina. 2014. N 4. C. 179-185.


12. Otchet MKRZ po tkanevim reakciyam, rannim i otdalennim effektam v normalnih tkanyah i organah - porogovie dozi dlya tkanevih reakcii v kontekste radiacionnoi zashiti (Trydi MKRZ; Pyblikaciya 118). [F.A. Stuart i dr.; red.: A.V. Akleev, M.F. Kiselev; per. s angl.: E.M. Jidkova, N.S. Kotova]. Chelyabinsk: Kniga, 2012. 384 s.


13. Pastyhova E.I. Vliyanie hronicheskogo nizkointensivnogo izlycheniya na ishodi beremennostei i rodov y jenshin pribrejnih sel reki Techa. Avtoreferat dissertacii na soiskanie ychenoi stepeni kandidata biologicheskih nayk. Moskva, 2012. 22 c.


14. Pyblikaciya 103 Mejdynarodnoi Komissii po radiacionnoi zashite (MKRZ). Per s angl. (Pod obshei red. Kiseleva M.F. i Shandali N.K.). M.: Izd. OOO PKF «Alana», 2009. 344 s.


15. Sosnina S.F., Kabirova N.R., Okatenko P.V., Rogacheva S.A., Careva U.V., Gryzdeva E.A., Sokolnikov M.E. Registr zdorovya detskogo naseleniya g. Ozerska: rezyltati razrabotki, principi vedeniya, vozmojnosti i perspektivi / Medicina ekstremalnih sityacii. 2017. ? 3(61). C. 95-103.


16. Sosnina S.F., Okatenko P.V. Neinfekcionnaya patologiya y detei rabotnic predpriyatiya atomnoi promishlennosti / Medicinskii akademicheskii jyrnal. 2017. N 17(3). C. 68-76.


17. Asakawa J., Kamiguchi Y., Kamiya K., Nakamura N. Mutagenic effects of ionizing radiation on immature rat oocytes / Radiat. Res. 2014. Vol.182, N 4. P. 430-434.


18. Committee on Medical Aspects of Radiation in the Environment (COMARE). Seventeenth Report: Further consideration of the incidence of cancers around the nuclear installations at Sellafield and Dounreay. Public Health England, 2016. 284 p.


19. Kondrashova V.G., Kolpakov I.Ye., Vdovenko V.Yu., Grytsenko T.V., Shepeliuk T.V., Studenikina O.N., Stepanova Ye.I. Clinical and anamnestic features of pathology of gastrointestinal tract in children with syndrome of heart connective tissue dysplasia, born to parents irradiated in childhood due to the Chernobyl accident / Child's Health. 2014. Vol. 6, N 57. P. 57-60.


20. Nakamura N. Genetic effects of radiation in atomic-bomb survivors and their children: past, present and future / J Radiat Res (Tokyo). 2006. Vol. 47 (Suppl. B). B67-B73.


21. Neel J.V., Schull W.J. The Children of Atomic Bomb Survivors: A Genetic Study. Washington, D.C.: National Academy Press, 1991. 518 p.


22. NRC. Health risks from exposure to low levels of ionizing radiation (Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation, BEIR VII - Phase 2). National Research Council, National Academy Press, Washington D.C., 2006. 424 p.


23. Ozasa K., Grant E.J., Kodama K. Japanese Legacy Cohorts: The Life Span Study Atomic Bomb Survivor Cohort and Survivors' Offspring / J. Epidemiol. 2018. Vol. 28, N 4. P. 162-169.


24. Preston D.L., Lubin J.H., Pierce D.A. EPICURE User`s Guide. Seattle: Hirosoft International Corp., 1993. 330 p.


25. UNSCEAR. Sources, Effects and Risks of Ionizing Radiation. UNSCEAR 2013 Report. Volume II. Scientific annex B: Effects of radiation exposure of children. New York, 2013. 284 p.


26. Vasilenko EK, Khokhryakov VF, Miller SC, Fix JJ, Eckerman K, Choe DO, Gorelov M, Khokhryakov VV, Knyasev V, Krahenbuhl MP, Scherpelz RI, Smetanin M, Suslova KG, Vostrotin VV. Mayak Worker Dosimetry Study: an Overview / Health Physics. 2007. Vol. 93, N 3. P. 190-206.





Свидетельство о регистрации сетевого электронного научного издания N 077 от 29.11.2006
Журнал основан 16 ноября 2000г.
Выдано Министерством РФ по делам печати, телерадиовещания и средств массовых коммуникаций
(c) Перепечатка материалов сайта Medline.Ru возможна только с письменного разрешения редакции

Размещение рекламы

Rambler's Top100