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Vol. 21, Art. 39 (pp. 489-505)    |    2020       

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Non-tumor pathology in children of female workers of multi- industry mayak production association

Southern Urals Biophysics Institute, Russian Federation,
456780, Ozyorsk, 19 Ozerskoye shosse, Laboratory of Radiation Epidemiology

Brief summary

Retrospective epidemiological study was performed based on a cohort of personnel of Mayak Production Association (Mayak PA) employed in 1948-1982 and on the Ozyorsks children Health Registry. Incidence of non-tumor pathology was traced among 10581 children under 15; 1742 of them were offspring of 1266 Mayak PA female workers exposed to preconception radiation. Children of unexposed parents (n=8839) made the comparison group. Incidence rate of children?s morbidity by classes of non-tumor pathology was calculated. Statistical analysis was performed using nonparametric statistics. Comparing to a group of offspring of unexposed parents one may note statistically significant increase of incidence rate of chronic pathology of lower respiratory tract, allergodermathosis, diseases of upper gastrointestinal, pathologies of eye muscular system. Significant predominance over a group of unexposed parents was registered for endocrine diseases as a whole including non-tumor thyroid pathology with a significant contribution of a subgroup of girls, daughters of exposed mothers; for diseases of the musculoskeletal system and connective tissue including deforming dorsopathies; for diseases of the circulatory system due to non-rheumatic heart diseases. High incidence of polymorbidities was registered in a group of offspring of mothers exposed to radiation prior to conception. Dose categories of maternal preconception occupational exposure, in which there was a statistically significant excess of the level of non-tumor pathology in the offspring, are indicated. The detected differences do not exclude a specific role of preconception exposure of gonads in development of nonneoplastic pathology in offspring that requires further analysis.


Key words

non-tumor incidence, children, radiation, parental exposure, Mayak PA

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