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"Институт токсикологии Федерального медико-биологического агентства"

Институт теоретической и экспериментальной биофизики Российской академии наук.


Адрес редакции и реквизиты

199406, Санкт-Петербург, ул.Гаванская, д. 49, корп.2

ISSN 1999-6314

Российская поисковая система

Vol. 19, Art. 89 (pp. 1254-1264)    |    2018       

The effect of extent of glioblastoma resection on the progression-free period duration.
Gulyaev D.A., Krasnoshlyk P.V., Lahina YU.S., Petrov A.A.

Federal State Budgetary Institution V.A. Almazov National Medical Research Center, Saint Petersburg

Brief summary

The aim of our research is studying the effect of the radical removal of glioblastoma hyperintense on T2 Flair image area on the progression-free period duration. Now it is customary to refer to glioblastoma not only a hyperintense site on T1 post-contrast images, but also a zone of hyperintensive T2 Flair signal with peritumoral located, previously considered the area of perifocal oedema. Our work is based on a series of 19 observations of patients between the ages of 18 and 79, whose average age was 47.29 years; the sexual ratio was 1: 1.37 in favor of women who had been operated on for intracerebral high-grade glial tumors Sawaya II-III, using intraoperative electrophysiological monitoring and neuronavigation equipment. Patients with a preserved hyperintense signal in the T2 image detected by MRT, have no significant differences in life expectancy, regardless of the extent of the removal of this zone, but a significantly lower duration of the progression-free period compared to the group of observations of total tumor removal with the Flair zone. Thus, the zone of perifocal changes has great importance in predicting the disease prognosis, which may be related to its cellular composition, so it is important to research cell composition of the perifocal zone.

Key words

IDH mutation, MGMT gene promoter, hyperintense T2 Flair signal zone, extent of resection, prognosis.

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