Медико-биологический
информационный портал
для специалистов
 
БИОМЕДИЦИНСКИЙ ЖУРНАЛ Medline.ru

СОДЕРЖАНИЕ ЖУРНАЛА:
Физико-химическая биология

Клиническая медицина

Профилактическая медицина

Медико-биологические науки


АРХИВ:

Фундаментальные исследования

Организация здравохраниения

История медицины и биологии



Последние публикации

Поиск публикаций

Articles

Архив :  2000 г.  2001 г.  2002 г. 
               2003 г.  2004 г.  2005 г. 
               2006 г.  2007 г.  2008 г. 
               2009 г.  2010 г.  2011 г. 
               2012 г.  2013 г.  2014 г. 
               2015 г.  2016 г.  2017 г. 
               2018 г.  2019 г. 

Редакционная информация:
        Опубликовать статью
        Наша статистика


 РЕДАКЦИЯ:
Главный редактор

Заместители главного редактора

Члены редколлегии
Специализированные редколлегии


 УЧРЕДИТЕЛИ:
Федеральное государственное бюджетное учреждение науки
"Институт токсикологии Федерального медико-биологического агентства"
(ФГБУН ИТ ФМБА России)

Институт теоретической и экспериментальной биофизики Российской академии наук.

ООО "ИЦ КОМКОН".




Адрес редакции и реквизиты

199406, Санкт-Петербург, ул.Гаванская, д. 49, корп.2

ISSN 1999-6314

Российская поисковая система
Искать: 


«
Vol. 19, Art. 62 (pp. 861-879)    |    2018       
»

Obesity-related kidney disease: modern aspects of pathogenesis, diagnostics and treatment (review of the literature)
Salukhov V.V., Rudakov Yu.V., Shelukhin V.A., Kan E.A.

S.M. Kirov Military Medical Academy, Saint Petersburg, Russia



Brief summary

The review of the world literature devoted to the synthesis of modern aspects of epidemiology, pathogenesis, diagnosis and treatment of obesity-related kidney disease is presented. The problems of terminology and diagnosis of kidney damage in obesity are discussed. Genetic, hemodynamic and metabolic risk factors and molecular - cell mechanisms of damage to the major kidney compartments associated with obesity are presented. The results of experimental data obtained in a laboratory animal model and in cell culture, histological studies of autopsy material and nephrobiopaths of patients with obesity-related kidney disease are demonstrated. The main therapeutic strategies have been determined, taking into account current ideas about the pathophysiological mechanisms of the formation of chronic kidney disease associated with obesity.


Key words

оbesity, obesity-related kidney disease, glomerulopathy, hyperfiltration, chronic kidney disease.





(The article in PDF format. For preview need Adobe Acrobat Reader)



Open article in new window

Reference list

1. Preble W. Obesity: Observations on One Thousand Cases / W. Preble // The Boston Medical and Surgical Journal. - 1923. - V. 188, N 17 - R. 617-621.


2. The Nephrotic Syndrome: A Complication of Massive Obesity / J.R. Weisinger [et al.] // Annals of Internal Medicine. - 1974. - V. 81, N 4. - R. 440.


3. Obesity-related glomerulopathy: clinical and pathologic characteristics and pathogenesis / V.D. D'Agati [et al.] // Nat Rev Nephrol. - 2016. - 12. - R. 453-471.


4. The NLPR3 inflammasome and obesity-related kidney disease / Ben Ke [et al.] // J Cell Mol Med. - 2018. - V. 22, N 1 - R. 16-24.


5. Comparison of visceral, body fat indices and anthropometric measures in relation to chronic kidney disease among Chinese adults from a large scale cross-sectional study / Y. Dong [et al] // BMC Nephrol. - 2018. - V. 19, N 1. - R. 40.


6. Association of age and BMI with kidney function and mortality: a cohort study / J.L. Lu [et al.] // Lancet Diabetes Endocrinol. - 2015. - R. 704-714.


7. Comparison between different measures of body fat with kidney function decline and incident CKD / M. Madero [et al.] // Clin. J Am Soc. Nephrol. - 2017. - N12. - R. 893-903.


8. Body mass index and risk of advanced chronic kidney disease: prospective analyses from a primary care cohort of 1.4 million adults in England / W.G. Herrington // PLoS One 12. - 2017. - e0173515.


9. Connie M. Rhee. The dual roles of obesity in chronic kidney disease: a review of the current literature / M. Rhee Connie, Seyed-Foad Ahmadi; Kamyar Kalantar-Zadeh // Current Opinion in Nephrology and Hypertension. - 2016. - V.25, N 3. - R. 208-216.


10. Tsuboi Nobuo. The Renal Pathology of Obesity / Nobuo Tsuboi, Yusuke Okabayashi, Akira Shimizu, Takashi Yokoo // Kidney Int Rep. - 2017. - V. 2, N 2. - R. 251-260.


11. Albuminuria changes are associated with subsequent risk of end-stage renal disease and mortality / J.J. Carrero [et al.] // Kidney Int. - 2017. - N 91. - R. 244-251.


12. Smirnov A.V. Problema ocenki skorosti klybochkovoi filtracii pri ojirenii / A.V. Smirnov, I.G. Kaukov, A.Sh. Rymyancev // Nefrologiya - 2017. - V. 21, N 2. - S. 20-23.


13. Predictive performance of 12 equations for estimating glomerular filtration rate in severely obese patients / Serpa Neto A [et al.] // Einstein (Sao Paulo). - 2011. - V. 9, N 3. - R. 294-301.


14. Salazar D.E. Predicting creatinine clearance and renal drug clearance in obese patients from estimated fat-free body mass / D.E. Salazar, G.B. Corcoran // Am. J. Med. - 1988. - ?84. - R. 1053-1060.


15. Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders / S.S. Choe [et al.] // Frontiers in Endocrinology. - 2016. - V.7. -N 30. - Rejim dostypa: http://doi.org/10.3389/ fendo.2016.00030.


16. Kovesdi Ch. Ojirenie i zabolevaniya pochek: skritie posledstviya epidemii / Ch. Kovesdi, S. Fyrs, K. Zokkali // Nefrologiya. - 2017. - V. 21, N 2. - S. 9.


17. Li C. Intrarenal renin-angiotensin system mediates fatty acid-induced ER stress in the kidney / C. Li, Y. Lin, R. Luo // Am. J. Physiol. Renal Physiol. - 2016. - R. 351-363.


18. The Association Between Metabolically Healthy Obesity and the Risk of Proteinuria: The Kansai Healthcare Study / S. Uehara [et al.] // Bmc Nephrol. - 2018 - N 19.- R. 40.


19. Focal and segmental glomerulosclerosis: clinical and kidney biopsy correlations / S. Sethi [et al.] // Clin. Kidney J. - 2014. - N 7. - R. 531-537.


20. Tsuboi N. Low glomerular density with glomerulomegaly in obesity-related glomerulopathy / N.Tsuboi, Y.Utsunomiya, G.Kanzaki // Clin. J. Am. Soc. Nephrol. -2012. - N7. - R. 735-741.


21. Ross M.H. Histology: A Text and Atlas: With Correlated Cell and Molecular Biology (7th Edition) / M.H. Ross, W.Pawlina // Wolters Kluwer Health. Print book. - 2016. - P. 584-625.


22. Amman K. Structural renal changes in obesity and diabetes / K. Amman, K. Benz // Semin Nephrol. - 2013. - V. 33, N 1. - R. 23-33.


23. Tsuboi N. Factors related to the glomerular size in renal biopsies of chronic kidney disease patients / N. Tsuboi, Y. Utsunomiya, K. Koike // Clin Nephrol. - 2013. - N79. - R.277-284.


24. Obesity-related glomerulopathy and podocyte injury: a mini review Front Biosci (Elite Ed) Author manuscript / M. Camici [et al] // Front Biosci (Elite Ed). - 2012. - R.1058-1070.


25. Arribas J. ADAM17 as a therapeutic target in multiple diseases / J.Arribas, C.Esselens // Curr. Pharm. Des. - 2009 - V. 15, N 20. - R. 2319-2335.


26. Chikusetsu saponin IVa ameliorates high fat diet‐induced inflammation in adipose tissue of mice through inhibition of NLRP3 inflammasome activation and NF kappaB signaling / C Yuan [et al.] // Oncotarget. - 2017. - N 8. - R. 31023-31040.


27. The Inflammasomes and Autoinflammatory Syndromes / L. Broderick [et al.] // Annu Rev. Pathol. Mech. Dis. - 2015. - V. 10, ? 1. - R.395-424. - doi:10.1146/annurev-pathol-012414-040431.


28. Role of innate and adaptive immunity in obesity / T.McLaughlin [et al.] // J Clin Invest. - 2017. - V.127, N 1. - P.5-13.


29. Aliskiren restores renal AQP2 expression during unilateral ureteral obstruction by inhibiting the inflammasome / W. Wang [et al.] // Am. J. Physiol. Renal Physiol. - 2015. - Vol. 308. - R. 10-22.


30. NLRP3 inflammasome activation is involved in Ang II induced kidney damage via mitochondrial dysfunction / Y. Wen [et al.] // Oncotarget. - 2016. - N7. - R 54290 - 54302.


31. Mitochondrial reactive oxygen species mediated NLRP3 inflammasome activation contributes to aldosterone induced renal tubular cells injury / W. Ding [et al.] // Oncotarget. - 2016. - N7. - R. 17479-17491.


32. Involvement of endoplasmic reticulum stress in angiotensin II induced NLRP3 inflammasome activation in human renal proximal tubular cells in vitro / J. Wang [et al.] // Acta Pharmacol. Sin. - 2015. - N 36. - R. 821-830.


33. NLRP3 inflammasome activation contributes to aldosterone induced podocyte injury / M. Bai [et al.] // Am. J. Physiol. Renal Physiol. - 2017. - N 312. - R. 556-564.


34. Comparison of visceral and body fat indices and anthropometric measures in relation to untreated hypertension by age and gender among Chinese / J. Jiang [et al.] // Int J Cardiol. - 2016. - N 219. - R. 204-211.


35. Prevalence of overweight, obesity, abdominal obesity and obesity-related risk factors in southern China / L. Hu [et al.] // PLoS One. - 2017. - V. 12, N9. - e0183934.


36. The association of chronic kidney disease and waist circumference and waist-to-height ratio in Chinese urban adults / Y. He [et al.] // Medicine (Baltimore). - 2016. - N 95. - e3769.


37. Won-Kyung Cho. Obesity and chronic kidney disease: A population-based study among South Koreans / Cho Won-Kyung // PLoS One. - 2018. - V. 13, N 2. - e0193559.


38. Obesity-related glomerulopathy and podocyte injury: a mini review Front Biosci (Elite Ed) Author manuscript / M. Camici [et al.] // Published in final edited form as:Front Biosci (Elite Ed). - 2012. - N 4. - R. 1058-1070.


39. Anders H.J. The intestinal microbiota, a leaky gut, and abnormal immunity in kidney disease / H.J. Anders, K.Andersen, B. Stecher // Kidney Int. - 2013. - N 83 - R. 1010-1016.


40. Altshuler Keylin S. Mitochondrial homeostasis in adipose tissue remodeling / S. Altshuler Keylin, S. Kajimura // Sci Signal. - 2017. - N 10. - Rejim dostypa: http://doi:10.1126/scisignal.aai9248.


41. Protection of mitochondria prevents high fat diet induced glomerulopathy and proximal tubular injury / H.H. Szeto [et al.] // Kidney Int. - 2016. - N 90. - R. 997-1011.


42. Whaley Connell A. Obesity and kidney disease: from population to basic science and the search for new therapeutic targets / A.Whaley Connell, J.R. Sowers // Kidney Int. - 2017. - N 92. - R. 313-323.


43. The effectiveness of pharmaceutical interventions for obesity: weight loss with orlistat and sibutramine in a United Kingdom population-based cohort / I.J. Douglas [et al.] // Br J Clin Pharmacol. - 2015. - N79. - R.1020-1027.


44. Nefrologicheskie aspekti hiryrgicheskoi korrekcii massi tela pri morbidnom ojirenii / I. N. Bobkova [i dr.] // Terapevticheskii arhiv. - 2018. - N 06. - S. 98-104.


45. Bariatric surgery is associated with improvement in kidney outcomes / A.R. Chang [et al.] // Kidney Int. - 2016. - N 90. - R. 164-171.


46. Long-term normal renal function after drastic weight reduction in patients with obesity-related glomerulopathy / A. Serra [et al.] // Obes. Facts - 2015. - N 8. - R. 188-199.


47. Zingerman B. Effect of acetazolamide on obesity-induced glomerular hyperfiltration: a randomized controlled trial / B. Zingerman, M. Herman-Edelstein, A.Erman // PLoS One. - 2015. -?10 - e0137163.


48. Laplante M. mTOR signaling in growth control and disease / M. Laplante, D. M. Sabatini // Cell. - 2012. - ? 149. - R. 274-293.


49. Autophagic Dysfunction in Type 2 Diabetes Mellitus: Pathophysiology and Therapeutic Implications / T. J. Islam [et al.] // Diabetes & Metab. - 2017. - N 8. - R. 5.


50. Stabler Th.V. Chondroitin Sulfate Inhibits Monocyte Chemoattractant Protein-1 Release From 3T3-L1 Adipocytes: A New Treatment Opportunity for Obesity-Related Inflammation? / Th.V. Stabler, E.Montell, J. Vergés // Biomarker Insights. - 2017. - N 12. - R. 1-4.





Свидетельство о регистрации сетевого электронного научного издания N 077 от 29.11.2006
Журнал основан 16 ноября 2000г.
Выдано Министерством РФ по делам печати, телерадиовещания и средств массовых коммуникаций
(c) Перепечатка материалов сайта Medline.Ru возможна только с письменного разрешения редакции

Размещение рекламы

Rambler's Top100