Медико-биологический
информационный портал
для специалистов
 
БИОМЕДИЦИНСКИЙ ЖУРНАЛ Medline.ru

СОДЕРЖАНИЕ ЖУРНАЛА:
Физико-химическая биология

Клиническая медицина

Профилактическая медицина

Медико-биологические науки


АРХИВ:

Фундаментальные исследования

Организация здравохраниения

История медицины и биологии



Последние публикации

Поиск публикаций

Articles

Архив :  2000 г.  2001 г.  2002 г. 
               2003 г.  2004 г.  2005 г. 
               2006 г.  2007 г.  2008 г. 
               2009 г.  2010 г.  2011 г. 
               2012 г.  2013 г.  2014 г. 
               2015 г.  2016 г.  2017 г. 
               2018 г.  2019 г. 

Редакционная информация:
        Опубликовать статью
        Наша статистика


 РЕДАКЦИЯ:
Главный редактор

Заместители главного редактора

Члены редколлегии
Специализированные редколлегии


 УЧРЕДИТЕЛИ:
Федеральное государственное бюджетное учреждение науки
"Институт токсикологии Федерального медико-биологического агентства"
(ФГБУН ИТ ФМБА России)

Институт теоретической и экспериментальной биофизики Российской академии наук.

ООО "ИЦ КОМКОН".




Адрес редакции и реквизиты

199406, Санкт-Петербург, ул.Гаванская, д. 49, корп.2

ISSN 1999-6314

Российская поисковая система
Искать: 


«
Vol. 19, Art. 26 (pp. 352-362)    |    2018       
»

Elements of urine sediment and interleukin-18 in acute kidney injury after cardiac surgery
North-Western State Medical University named after I.I. Mechnikov



Brief summary

Changes in the composition of urine sediment and concentration of interleukin-18 (IL-18) in urine were studied 2, 4 and 24 hours after various cardiosurgical interventions in 111 patients divided into 2 groups, taking into account EuroSCORE II scale. In patients of the 1-st group with acute kidney injury (AKI) and glomerular filtration rate (GFR) > 85 ml/min, maximum concentration increase in comparison with initial level (before surgery) was detected 2 hours after surgery for IL-18, through 4 hours for hyaline casts and 24 hours for renal tubular epithelial cells. In urine of patients in this group without AKI, concentration of IL-18, hyaline casts and renal tubular epithelial cells at same time of observation was significantly lower than in patients with AKI. In patients of 2-nd group (GFR 50 - 85 ml/min) with AKI and without AKI, there were no differences in IL-18 concentration in urine at 2, 4 and 24 hours after cardiac surgery. In patients of 2-nd group with AKI maximum increase in concentration of hyaline casts was detected after 4 hours, and cells of renal epithelium 24 hours after cardiac surgery, and their concentration was significantly higher than in patients without AKI. The maximal concentration of IL-18, hyaline casts and cells of renal tubular epithelium patients in 2-nd group with AKI was significantly lower than corresponding values in patients of 1-st group with AKI. Thus, early informative laboratory markers of AKI after cardiac surgery can be IL-18, renal tubular epithelial cells and hyaline casts only in patients whose glomerular filtration rate is above 85 ml/min.


Key words

cardiac surgery, acute kidney injury, phase-contrast microscopy, urine sediment, renal tubular epithelial cells, hyaline casts, interleukin-18.





(The article in PDF format. For preview need Adobe Acrobat Reader)



Open article in new window

Reference list

1. Sokolov D.V. Ostroe pochechnoe povrejdenie v perioperacionnom periode / D.V. Sokolov, U.S. Polyshin // Vestnik anesteziologii i reanimatologii. - 2018. - N 1. - S. 46-54.


2. Cardiac surgery-associated acute kidney injury / H. Mao, N. Katz, W. Ariyanon, et al. // Cardio Renal Medicine - 2013. - Vol. 3. - P. 178-199.


3. Khwaja A. KDIGO Clinical Practice Guidelines for Acute Kidney Injury / A. Khwaja // Nephron Clinical Practice - 2012. - Vol. 120. ‒ P. 179-184.


4. Recent developments in the detection and management of acute kidney injury / J. McCaffrey, A. Dhaka, D. Milford et al. // Arch. Dis. Child. - 2017. - Vol. 102. ‒ P. 91-96.


5. Smirnov A.V. Ostroe povrejdenie pochek / A.V. Smirnov, V.A. Dobronravov, A.Sh. Rymyancev, I.G. Kaukov. ‒ M.: Izd-vo Medicinskoe informacionnoe agentstvo, 2015. ‒ 488 s.


6. Perazella M.A. The Urine Sediment as a Biomarker of Kidney Disease / M.A. Perazella // American Journal of Kidney Diseases. - 2015. - Vol. 66. - P. 748-755.


7. The new EuroSCORE II does not improve prediction of mortality in high-risk patients undergoing cardiac surgery: a collaborative analysis of two European centres / N. Howell, S. Head, N. Freemantle et al. // European Journal of Cardio-Thoracic Surgery. ‒ 2013. ‒ Vol. 44. ‒ P. 1006-1011.


8. Cockcroft D.W. Prediction of creatinine clearance from serum creatinine. / D.W. Cockcroft, M.H. Gault Nephron. - 1976. - Vol. 16. - P. 31-41.


9. Fogazzi G.B. The urinary sediment an integrated view / G.B. Fogazzi. - Trento: Printer Trento, 2010. ‒ 289 p.


10. Urinary Sediment Cast Scoring Index for Acute Kidney Injury: A Pilot Study / L.S. Chawla, A. Dommu, A. Berger et al. // Nephron Clinical Practice. - 2008. - Vol. 110. - P. 145-150.


11. Bonventre J.V. Cellular pathophysiology of ischemic acute kidney injury / J.V. Bonventre // The Journal of Clinical Investigation. - 2011. - Vol. 121. - P. 4210-4221.


12. Caleffi A. Cylindruria / A. Caleffi, G. Lippi // Clinical Chemistry Laboratory Medicine. - 2015. - Vol. 53. - P. 1471-1477.


13. Schnaper H.W. Remnant nephron physiology and the progression of chronic kidney disease / H.W. Schnaper // Pediatr. Nephrol. - 2014. - Vol. 29. - P. 1-17.



Свидетельство о регистрации сетевого электронного научного издания N 077 от 29.11.2006
Журнал основан 16 ноября 2000г.
Выдано Министерством РФ по делам печати, телерадиовещания и средств массовых коммуникаций
(c) Перепечатка материалов сайта Medline.Ru возможна только с письменного разрешения редакции

Размещение рекламы

Rambler's Top100