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Vol. 19, Art. 18 (pp. 249-257)    |    2018       

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The role of autologous hemаtopoietic stem cell transplantation in patients with diffuse large B-cell lymphoma with adverse factors of prognosis

Samarina S.V., Nazarova E.L., Minaeva N.V., Zorina N.A., Khorobrykh M.N., Zotina E.N. Federal State Budget Institution of ScienceKirov Scientific Research Institute of Hematology and Blood Transfusion of Federal Medical Biological Agency, 72 Krasnoarmeyskaya str., Kirov, Russian Federation, 610027.

Gritsaev S.V. 2Federal State Budget Institution Russian Research Institution of Hematology and Transfusiology of Federal Medical Biological Agency, 2-ya Sovetskaya str., 16, Saint-Petersburg, Russian Federation, 191024.

Brief summary

To determine the role of autologous stem cell transplantation (autoHSCT) in the treatment of patients with diffuse large B-cell lymphoma (DLBCL) and rationale to the need of improving the postremission therapy retrospective analyses of 38 patients survival has been made. Three groups of patients were formed according to the effectiveness of induction and reinduction therapy and carrying out of autoHSCT. Median of follow-up period was 51 months. Оverall survival was worse in patients with early relapse and resistant form of DLBCL without autoHSCT compared with patients to whom transplantation was performed in first remission or in relapse: 10 months vs the median, which not achieved in the second and third groups (р<0,001). The conclusion is - the advisability of autoHSCT including in the treatment algorithm of patients with unfavorable types of DLBCL and the need to develop new treatment approaches in elderly or comorbidity patients who can not perform autoHSCT.


Key words

diffuse large B-cell lymphoma, transplantation, hematopoietic stem cells, overall survival, disease prognosis.

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